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GPCR

NameProstaglandin F2-alpha receptor
SpeciesMus musculus (Mouse)
GenePtgfr
SynonymPGF receptor
Prostanoid FP receptor
prostaglandin F2-alpha receptor
PF2AR
prostaglandin F receptor (FP)
[ Show all ]
DiseaseN/A for non-human GPCRs
Length366
Amino acid sequenceMSMNSSKQPVSPAAGLIANTTCQTENRLSVFFSIIFMTVGILSNSLAIAILMKAYQRFRQKSKASFLLLASGLVITDFFGHLINGGIAVFVYASDKDWIRFDQSNILCSIFGISMVFSGLCPLFLGSAMAIERCIGVTNPIFHSTKITSKHVKMILSGVCMFAVFVAVLPILGHRDYQIQASRTWCFYNTEHIEDWEDRFYLLFFSFLGLLALGVSFSCNAVTGVTLLRVKFRSQQHRQGRSHHLEMIIQLLAIMCVSCVCWSPFLVTMANIAINGNNSPVTCETTLFALRMATWNQILDPWVYILLRKAVLRNLYKLASRCCGVNIISLHIWELSSIKNSLKVAAISESPAAEKESQQASSEAGL
UniProtP43117
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL5000
IUPHAR344
DrugBankN/A

Ligand

NameProstaglandin E2
Molecular formulaC20H32O5
IUPAC name(Z)-7-[(1R,2R,3R)-3-hydroxy-2-[(E,3S)-3-hydroxyoct-1-enyl]-5-oxocyclopentyl]hept-5-enoic acid
Molecular weight352.471
Hydrogen bond acceptor5
Hydrogen bond donor3
XlogP2.8
Synonyms(-)-Prostaglandin E2
(15S)-Prostaglandin E2
(5Z,11-alpha,13E,15S)-11,15-Dihydroxy-9-oxoprosta-5,13-dien-1-oic acid
(5Z,11.alpha.,13E,15S)-11,15-Dihydroxy-9-oxoprosta-5,13-dien-1-oic acid
(5Z,11?,13E,15S)-11,15-Dihydroxy-9-oxo-prosta-5,13-dien-1oic acid
[ Show all ]
Inchi KeyXEYBRNLFEZDVAW-ARSRFYASSA-N
Inchi IDInChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-17,19,21,23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t15-,16+,17+,19+/m0/s1
PubChem CID5280360
ChEMBLCHEMBL548
IUPHAR1883, 1916
BindingDB35847
DrugBankDB00917

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Ki100.0 nMPMID9313928BindingDB,IUPHAR

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