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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	5-hydroxytryptamine receptor 4
Species	Rattus norvegicus (Rat)
Gene	Htr4
Synonym	5-HT-4 5-HT4 5-HT4 receptor 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled serotonin receptor 4
Disease	N/A for non-human GPCRs
Length	406
Amino acid sequence	MDRLDANVSSNEGFGSVEKVVLLTFFAMVILMAILGNLLVMVAVCRDRQLRKIKTNYFIVSLAFADLLVSVLVNAFGAIELVQDIWFYGEMFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMTPLRIALMLGGCWVIPMFISFLPIMQGWNNIGIVDVIEKRKFNHNSNSTFCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAQQIQMLQRAGATSESRPQTADQHSTHRMRTETKAAKTLCVIMGCFCFCWAPFFVTNIVDPFIDYTVPEKVWTAFLWLGYINSGLNPFLYAFLNKSFRRAFLIILCCDDERYKRPPILGQTVPCSTTTINGSTHVLRDTVECGGQWESRCHLTATSPLVAAQPVIRRPQDNDLEDSCSLKRSQS
UniProt	Q62758
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL4317
IUPHAR	9
DrugBank	N/A

Ligand

Name	CHEMBL116913
Molecular formula	C16H22ClN3O3
IUPAC name	7-amino-6-chloro-10,13-dioxa-2,16-diazatricyclo[14.2.2.04,9]icosa-4,6,8-trien-3-one
Molecular weight	339.82
Hydrogen bond acceptor	5
Hydrogen bond donor	2
XlogP	1.3
Synonyms	BDBM50122871 7-Amino-6-chloro-10,13-dioxa-2,16-diaza-tricyclo[14.2.2.04,9]icosa-4,6,8-trien-3-one
Inchi Key	CEOCEXSTLLSYBV-UHFFFAOYSA-N
Inchi ID	InChI=1S/C16H22ClN3O3/c17-13-9-12-15(10-14(13)18)23-8-7-22-6-5-20-3-1-11(2-4-20)19-16(12)21/h9-11H,1-8,18H2,(H,19,21)
PubChem CID	11724799
ChEMBL	CHEMBL116913
IUPHAR	N/A
BindingDB	50122871
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	29.7 nM	Bioorg. Med. Chem. Lett., (1995) 5:8:795, PMID12540230	BindingDB,ChEMBL
Ki	30.0 nM	N/A	BindingDB

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