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GPCR

NameTrace amine-associated receptor 1
SpeciesRattus norvegicus (Rat)
GeneTaar1
SynonymTRAR1
TaR-1
Trace amine receptor 1
TAR1
TA1 receptor
DiseaseN/A for non-human GPCRs
Length332
Amino acid sequenceMHLCHNSANISHTNSNWSRDVRASLYSLISLIILTTLVGNLIVIISISHFKQLHTPTNWLLHSMAVVDFLLGCLVMPYSMVRTVEHCWYFGELFCKLHTSTDIMLSSASILHLAFISIDRYYAVCDPLRYKAKINLAAIFVMILISWSLPAVFAFGMIFLELNLEGVEELYHNQVFCLRGCFPFFSKVSGVLAFMTSFYIPGSVMLFVYYRIYFIAKGQARSINRANLQVGLEGESRAPQSKETKAAKTLGIMVGVFLLCWCPFFFCMVLDPFLGYVIPPTLNDTLNWFGYLNSAFNPMVYAFFYPWFRRALKMVLFGKIFQKDSSRSKLFL
UniProtQ923Y9
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3833
IUPHAR364
DrugBankN/A

Ligand

NameCHEMBL202335
Molecular formulaC17H18F3NO
IUPAC nameN-methyl-2-[4-[[4-(trifluoromethyl)phenyl]methoxy]phenyl]ethanamine
Molecular weight309.332
Hydrogen bond acceptor5
Hydrogen bond donor1
XlogP4.1
SynonymsBDBM50181798
N-methyl-O-(p-trifluoromethyl)benzyl-tyramine
Inchi KeyCFDWXJABGQMTCO-UHFFFAOYSA-N
Inchi IDInChI=1S/C17H18F3NO/c1-21-11-10-13-4-8-16(9-5-13)22-12-14-2-6-15(7-3-14)17(18,19)20/h2-9,21H,10-12H2,1H3
PubChem CID11537512
ChEMBLCHEMBL202335
IUPHARN/A
BindingDB50181798
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
EC5061.0 nMPMID16451074BindingDB,ChEMBL

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