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Name | Gastrin/cholecystokinin type B receptor |
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Species | Rattus norvegicus (Rat) |
Gene | Cckbr |
Synonym | CHOLREC Cholecystokinin-2 receptor CCK2-R CCK2 receptor CCK-BR [ Show all ] |
Disease | N/A for non-human GPCRs |
Length | 452 |
Amino acid sequence | MELLKLNRSVQGPGPGSGSSLCRPGVSLLNSSSAGNLSCDPPRIRGTGTRELEMAIRITLYAVIFLMSVGGNVLIIVVLGLSRRLRTVTNAFLLSLAVSDLLLAVACMPFTLLPNLMGTFIFGTVICKAISYLMGVSVSVSTLNLVAIALERYSAICRPLQARVWQTRSHAARVILATWLLSGLLMVPYPVYTMVQPVGPRVLQCMHRWPSARVQQTWSVLLLLLLFFIPGVVIAVAYGLISRELYLGLHFDGENDSETQSRARNQGGLPGGAAPGPVHQNGGCRPVTSVAGEDSDGCCVQLPRSRLEMTTLTTPTPGPVPGPRPNQAKLLAKKRVVRMLLVIVLLFFLCWLPVYSVNTWRAFDGPGAQRALSGAPISFIHLLSYVSACVNPLVYCFMHRRFRQACLDTCARCCPRPPRARPQPLPDEDPPTPSIASLSRLSYTTISTLGPG |
UniProt | P30553 |
Protein Data Bank | N/A |
GPCR-HGmod model | N/A |
3D structure model | No available structures or models |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL3508 |
IUPHAR | 77 |
DrugBank | N/A |
Name | netazepide |
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Molecular formula | C28H30N6O3 |
IUPAC name | 1-[(3R)-1-(3,3-dimethyl-2-oxobutyl)-2-oxo-5-pyridin-2-yl-3H-1,4-benzodiazepin-3-yl]-3-[3-(methylamino)phenyl]urea |
Molecular weight | 498.587 |
Hydrogen bond acceptor | 6 |
Hydrogen bond donor | 3 |
XlogP | 3.8 |
Synonyms | 1-[(R)-1-(3,3-Dimethyl-2-oxo-butyl)-2-oxo-5-pyridin-2-yl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl]-3-(3-methylamino-phenyl)-urea C104428000 Gastrin inhibitor, Ferring PDSP2_000881 YF476 [ Show all ] |
Inchi Key | YDZYKNJZCVIKPP-VWLOTQADSA-N |
Inchi ID | InChI=1S/C28H30N6O3/c1-28(2,3)23(35)17-34-22-14-6-5-12-20(22)24(21-13-7-8-15-30-21)32-25(26(34)36)33-27(37)31-19-11-9-10-18(16-19)29-4/h5-16,25,29H,17H2,1-4H3,(H2,31,33,37)/t25-/m0/s1 |
PubChem CID | 9870520 |
ChEMBL | CHEMBL324547 |
IUPHAR | 887 |
BindingDB | 50056102 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
IC50 | 0.1 nM | PMID9022799 | BindingDB,ChEMBL |
Kd | 0.0794 nM | PMID16570921 | BindingDB |
Kd | 0.07943 nM | PMID17536796, PMID16570921 | ChEMBL |
pKb | 9.9 - | PMID18201065 | ChEMBL |
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