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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Probable G-protein coupled receptor 142
Species	Homo sapiens (Human)
Gene	GPR142
Synonym	AXOR103 G-protein coupled receptor PGR2 GPR142 KIF19
Disease	N/A
Length	462
Amino acid sequence	MSIMMLPMEQKIQWVPTSLQDITAVLGTEAYTEEDKSMVSHAQKSQHSCLSHSRWLRSPQVTGGSWDLRIRPSKDSSSFRQAQCLRKDPGANNHLESQGVRGTAGDADRELRGPSEKATAGQPRVTLLPTPHVSGLSQEFESHWPEIAERSPCVAGVIPVIYYSVLLGLGLPVSLLTAVALARLATRTRRPSYYYLLALTASDIIIQVVIVFAGFLLQGAVLARQVPQAVVRTANILEFAANHASVWIAILLTVDRYTALCHPLHHRAASSPGRTRRAIAAVLSAALLTGIPFYWWLDMWRDTDSPRTLDEVLKWAHCLTVYFIPCGVFLVTNSAIIHRLRRRGRSGLQPRVGKSTAILLGITTLFTLLWAPRVFVMLYHMYVAPVHRDWRVHLALDVANMVAMLHTAANFGLYCFVSKTFRATVRQVIHDAYLPCTLASQPEGMAAKPVMEPPGLPTGAEV
UniProt	Q7Z601
Protein Data Bank	N/A
GPCR-HGmod model	Q7Z601
3D structure model	This predicted structure model is from GPCR-EXP Q7Z601.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL2069161
IUPHAR	132
DrugBank	N/A

Ligand

Name	CHEMBL2164854
Molecular formula	C31H34N6O2
IUPAC name	(2S)-N-[1-[2-(dimethylamino)ethyl]-2-oxo-5-pyridin-4-ylpyridin-3-yl]-3-phenyl-2-[(1-pyridin-2-ylcyclopropyl)amino]propanamide
Molecular weight	522.653
Hydrogen bond acceptor	6
Hydrogen bond donor	2
XlogP	2.3
Synonyms	BDBM50395781
Inchi Key	CFUQJRQSRBNLSO-SANMLTNESA-N
Inchi ID	InChI=1S/C31H34N6O2/c1-36(2)18-19-37-22-25(24-11-16-32-17-12-24)21-27(30(37)39)34-29(38)26(20-23-8-4-3-5-9-23)35-31(13-14-31)28-10-6-7-15-33-28/h3-12,15-17,21-22,26,35H,13-14,18-20H2,1-2H3,(H,34,38)/t26-/m0/s1
PubChem CID	71462293
ChEMBL	CHEMBL2164854
IUPHAR	N/A
BindingDB	50395781
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand is heavier than 500 daltons.

Experimental Data

Parameter	Value	Reference	Database source
EC50	280.0 nM	PMID22926069	BindingDB,ChEMBL
Emax	118.0 %	PMID22926069	ChEMBL

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