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GPCR

Name5-hydroxytryptamine receptor 7
SpeciesRattus norvegicus (Rat)
GeneHtr7
SynonymGPRFO
5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled
5-HTx
5-HT7 receptor
5-HT7
[ Show all ]
DiseaseN/A for non-human GPCRs
Length448
Amino acid sequenceMMDVNSSGRPDLYGHLRSLILPEVGRGLQDLSPDGGAHPVVSSWMPHLLSGFLEVTASPAPTWDAPPDNVSGCGEQINYGRVEKVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGWAQNVNDDKVCLISQDFGYTIYSTAVAFYIPMSVMLFMYYQIYKAARKSAAKHKFPGFPRVQPESVISLNGVVKLQKEVEECANLSRLLKHERKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCSCIPLWVERTCLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQYRNINRKLSAAGMHEALKLAERPERSEFVLQNSDHCGKKGHDT
UniProtP32305
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3223
IUPHAR12
DrugBankN/A

Ligand

NameCHEMBL240729
Molecular formulaC48H66N4O4
IUPAC name1-(2-methoxyphenyl)-4-[2-[3-[10-[3-[2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl]phenoxy]decoxy]phenyl]ethyl]piperazine
Molecular weight763.08
Hydrogen bond acceptor8
Hydrogen bond donor0
XlogP10.9
SynonymsBDBM50213541
1,10-bis-[3-[2-[4-(2-methoxyphenyl)piperazin-1-yl]-ethyl]phenoxy]decane
Inchi KeyCFWSAXZHOITROD-UHFFFAOYSA-N
Inchi IDInChI=1S/C48H66N4O4/c1-53-47-23-11-9-21-45(47)51-33-29-49(30-34-51)27-25-41-17-15-19-43(39-41)55-37-13-7-5-3-4-6-8-14-38-56-44-20-16-18-42(40-44)26-28-50-31-35-52(36-32-50)46-22-10-12-24-48(46)54-2/h9-12,15-24,39-40H,3-8,13-14,25-38H2,1-2H3
PubChem CID44437332
ChEMBLCHEMBL240729
IUPHARN/A
BindingDB50213541
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand is heavier than 500 daltons.
This ligand has a partition coefficient log P greater than 5.

Experimental Data

ParameterValueReferenceDatabase source
Ki28.3 nMPMID17517509BindingDB,ChEMBL
Ki258.0 nMPMID17517509BindingDB,ChEMBL

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