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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Hydroxycarboxylic acid receptor 2
Species	Homo sapiens (Human)
Gene	HCAR2
Synonym	G protein-coupled receptor 109A PUMAG Nicotinic acid receptor Nic1 Niacr1 Niacin receptor 1 G-protein coupled receptor 109A G-protein coupled receptor HM74A HCA2 receptor [ Show all ]
Disease	Type 2 diabetes Hyperlipidaemia Major depressive disorder Cardiovascular disorder Atherosclerosis Arteriosclerosis Acute ischemic stroke [ Show all ]
Length	363
Amino acid sequence	MNRHHLQDHFLEIDKKNCCVFRDDFIVKVLPPVLGLEFIFGLLGNGLALWIFCFHLKSWKSSRIFLFNLAVADFLLIICLPFLMDNYVRRWDWKFGDIPCRLMLFMLAMNRQGSIIFLTVVAVDRYFRVVHPHHALNKISNRTAAIISCLLWGITIGLTVHLLKKKMPIQNGGANLCSSFSICHTFQWHEAMFLLEFFLPLGIILFCSARIIWSLRQRQMDRHAKIKRAITFIMVVAIVFVICFLPSVVVRIRIFWLLHTSGTQNCEVYRSVDLAFFITLSFTYMNSMLDPVVYYFSSPSFPNFFSTLINRCLQRKMTGEPDNNRSTSVELTGDPNKTRGAPEALMANSGEPWSPSYLGPTSP
UniProt	Q8TDS4
Protein Data Bank	N/A
GPCR-HGmod model	Q8TDS4
3D structure model	This predicted structure model is from GPCR-EXP Q8TDS4.
BioLiP	N/A
Therapeutic Target Database	T00864
ChEMBL	CHEMBL3785
IUPHAR	312
DrugBank	BE0000635

Ligand

Name	3-hydroxy-5-methylbenzoic acid
Molecular formula	C8H8O3
IUPAC name	3-hydroxy-5-methylbenzoic acid
Molecular weight	152.149
Hydrogen bond acceptor	3
Hydrogen bond donor	2
XlogP	1.5
Synonyms	3-Hydroxy-5-methyl-benzoic acid AC1Q5TRP AW5 CHEMBL2146905 FT-0757074 PubChem18175 TR-033310 Z1255523409 3-hydroxy-5-methylbenzoicacid AB0030856 AK-47209 BDBM50391819 CTK3J4996 KSC494S9N S-5999 3-HYDROX-5-METHYLBENZOIC ACID 4CH-003267 AC-944 AN-15441 CFXOUQXGRQXUSE-UHFFFAOYSA-N EN300-84081 NSC-28456 STL555376 585-81-9 ACT07354 BBL101580 CL8088 KB-32167 QC-10603 W-203198 ZINC1646464 3-methyl-5-hydroxy-benzoic acid AB1007712 AKOS005259855 Benzoic acid, 3-hydroxy-5-methyl- DB-072503 MCULE-6111297909 SCHEMBL987044 3-Hydroxy-5-methyl benzoic acid 5-Hydroxy-m-toluic acid AC1L5MDH ANW-48428 FS-2415 NSC28456 SY012261 X3116 3-hydroxy-5-methylbenzoic aicd 585H819 AJ-28686 BC203205 CS-0030557 KS-00000NMY RTR-033310 3,5-Cresotic acid 3-methyl-5-oxidanyl-benzoic acid AB52735 AM84165 BR-47209 DTXSID00207219 MolPort-005-933-293 ST2417734 [ Show all ]
Inchi Key	CFXOUQXGRQXUSE-UHFFFAOYSA-N
Inchi ID	InChI=1S/C8H8O3/c1-5-2-6(8(10)11)4-7(9)3-5/h2-4,9H,1H3,(H,10,11)
PubChem CID	231756
ChEMBL	CHEMBL2146905
IUPHAR	N/A
BindingDB	50391819
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	<1000000.0 nM	PMID24900524	BindingDB,ChEMBL

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