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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	Hydroxycarboxylic acid receptor 2
Species	Homo sapiens (Human)
Gene	HCAR2
Synonym	G-protein coupled receptor HM74A G-protein coupled receptor 109A PUMAG Nicotinic acid receptor HCA2 receptor Nic1 Niacin receptor 1 Niacr1 G protein-coupled receptor 109A [ Show all ]
Disease	Hyperlipidaemia Acute ischemic stroke Arteriosclerosis Atherosclerosis Cardiovascular disorder Major depressive disorder Type 2 diabetes [ Show all ]
Length	363
Amino acid sequence	MNRHHLQDHFLEIDKKNCCVFRDDFIVKVLPPVLGLEFIFGLLGNGLALWIFCFHLKSWKSSRIFLFNLAVADFLLIICLPFLMDNYVRRWDWKFGDIPCRLMLFMLAMNRQGSIIFLTVVAVDRYFRVVHPHHALNKISNRTAAIISCLLWGITIGLTVHLLKKKMPIQNGGANLCSSFSICHTFQWHEAMFLLEFFLPLGIILFCSARIIWSLRQRQMDRHAKIKRAITFIMVVAIVFVICFLPSVVVRIRIFWLLHTSGTQNCEVYRSVDLAFFITLSFTYMNSMLDPVVYYFSSPSFPNFFSTLINRCLQRKMTGEPDNNRSTSVELTGDPNKTRGAPEALMANSGEPWSPSYLGPTSP
UniProt	Q8TDS4
Protein Data Bank	N/A
GPCR-HGmod model	Q8TDS4
3D structure model	This predicted structure model is from GPCR-EXP Q8TDS4.
BioLiP	N/A
Therapeutic Target Database	T00864
ChEMBL	CHEMBL3785
IUPHAR	312
DrugBank	BE0000635

Ligand

Name	3-hydroxy-5-methylbenzoic acid
Molecular formula	C8H8O3
IUPAC name	3-hydroxy-5-methylbenzoic acid
Molecular weight	152.149
Hydrogen bond acceptor	3
Hydrogen bond donor	2
XlogP	1.5
Synonyms	3,5-Cresotic acid 3-HYDROX-5-METHYLBENZOIC ACID 3-Hydroxy-5-methyl benzoic acid 3-Hydroxy-5-methyl-benzoic acid 3-hydroxy-5-methylbenzoic aicd 3-hydroxy-5-methylbenzoicacid 3-methyl-5-hydroxy-benzoic acid 3-methyl-5-oxidanyl-benzoic acid 4CH-003267 5-Hydroxy-m-toluic acid 585-81-9 585H819 AB0030856 AB1007712 AB52735 AC-944 AC1L5MDH AC1Q5TRP ACT07354 AJ-28686 AK-47209 AKOS005259855 AM84165 AN-15441 ANW-48428 AW5 BBL101580 BC203205 BDBM50391819 Benzoic acid, 3-hydroxy-5-methyl- BR-47209 CFXOUQXGRQXUSE-UHFFFAOYSA-N CHEMBL2146905 CL8088 CS-0030557 CTK3J4996 DB-072503 DTXSID00207219 EN300-84081 FS-2415 FT-0757074 KB-32167 KS-00000NMY KSC494S9N MCULE-6111297909 MolPort-005-933-293 NSC-28456 NSC28456 PubChem18175 QC-10603 RTR-033310 S-5999 SCHEMBL987044 ST2417734 STL555376 SY012261 TR-033310 W-203198 X3116 Z1255523409 ZINC1646464 [ Show all ]
Inchi Key	CFXOUQXGRQXUSE-UHFFFAOYSA-N
Inchi ID	InChI=1S/C8H8O3/c1-5-2-6(8(10)11)4-7(9)3-5/h2-4,9H,1H3,(H,10,11)
PubChem CID	231756
ChEMBL	CHEMBL2146905
IUPHAR	N/A
BindingDB	50391819
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	<1000000.0 nM	PMID24900524	BindingDB,ChEMBL

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