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GPCR

NameGlucagon-like peptide 1 receptor
SpeciesHomo sapiens (Human)
GeneGLP1R
SynonymGLP-1-R
GLP-1 receptor
glucagon-like peptide 1 receptor
GLP-1R
DiseaseNon-insulin dependent diabetes
Type 2 diabetes
Type 1/2 diabetes
Type 1 diabetes
Obesity
[ Show all ]
Length463
Amino acid sequenceMAGAPGPLRLALLLLGMVGRAGPRPQGATVSLWETVQKWREYRRQCQRSLTEDPPPATDLFCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSSLPWRDLSECEESKRGERSSPEEQLLFLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLSCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGVPLLFVVPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQLEFRKSWERWRLEHLHIQRDSSMKPLKCPTSSLSSGATAGSSMYTATCQASCS
UniProtP43220
Protein Data Bank5vew, 5otv, 3c5t, 4zgm, 3iol, 5otu, 5vex, 5otw, 5otx, 3c59, 5nx2
GPCR-HGmod modelP43220
3D structure modelThis structure is from PDB ID 5vew.
BioLiPBL0418500,BL0418501, BL0418494,BL0418495, BL0380967, BL0143732, BL0143731, BL0379513,BL0379514, BL0418496,BL0418497, BL0143795, BL0143794, BL0378791,BL0378792, BL0167480, BL0167479, BL0324355,BL0324356, BL0418498,BL0418499, BL0324354, BL0380966
Therapeutic Target DatabaseT36075
ChEMBLCHEMBL1784
IUPHAR249
DrugBankBE0000857

Ligand

NameMLS000775736
Molecular formulaC29H31N5O5S
IUPAC nameN,N-dimethylformamide;2-(furan-2-yl)-N-[3-(3,4,5,6-tetrahydro-2H-azepin-7-ylsulfamoyl)phenyl]quinoline-4-carboxamide
Molecular weight561.657
Hydrogen bond acceptor7
Hydrogen bond donor2
XlogPNone
SynonymsAKOS007983651
CHEMBL1327418
HMS2756M12
MLS-0296687.0001
MLS002634127
[ Show all ]
Inchi KeyAFESFZWSOGZXGN-UHFFFAOYSA-N
Inchi IDInChI=1S/C26H24N4O4S.C3H7NO/c31-26(21-17-23(24-12-7-15-34-24)29-22-11-4-3-10-20(21)22)28-18-8-6-9-19(16-18)35(32,33)30-25-13-2-1-5-14-27-25;1-4(2)3-5/h3-4,6-12,15-17H,1-2,5,13-14H2,(H,27,30)(H,28,31);3H,1-2H3
PubChem CID16241726
ChEMBLCHEMBL1327418
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand is heavier than 500 daltons.
Partition coefficient log P of this ligand is not available.

Experimental Data

ParameterValueReferenceDatabase source
Potency10000.0 nMPubChem BioAssay data setChEMBL

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