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GPCR

NameThyrotropin-releasing hormone receptor
SpeciesHomo sapiens (Human)
GeneTRHR
SynonymThyroliberin receptor
TRH receptor
TRH-R
TRH-R1
TRH1 receptor
DiseaseUnspecified
Pain
Neurodegenerative disease
Endocrine disease
Cognitive disorders
[ Show all ]
Length398
Amino acid sequenceMENETVSELNQTQLQPRAVVALEYQVVTILLVLIICGLGIVGNIMVVLVVMRTKHMRTPTNCYLVSLAVADLMVLVAAGLPNITDSIYGSWVYGYVGCLCITYLQYLGINASSCSITAFTIERYIAICHPIKAQFLCTFSRAKKIIIFVWAFTSLYCMLWFFLLDLNISTYKDAIVISCGYKISRNYYSPIYLMDFGVFYVVPMILATVLYGFIARILFLNPIPSDPKENSKTWKNDSTHQNTNLNVNTSNRCFNSTVSSRKQVTKMLAVVVILFALLWMPYRTLVVVNSFLSSPFQENWFLLFCRICIYLNSAINPVIYNLMSQKFRAAFRKLCNCKQKPTEKPANYSVALNYSVIKESDHFSTELDDITVTDTYLSATKVSFDDTCLASEVSFSQS
UniProtP34981
Protein Data BankN/A
GPCR-HGmod modelP34981
3D structure modelThis predicted structure model is from GPCR-EXP P34981.
BioLiPN/A
Therapeutic Target DatabaseT77796
ChEMBLCHEMBL1810
IUPHAR363
DrugBankBE0008659

Ligand

NameMLS000554145
Molecular formulaC19H21N3OS
IUPAC name1-benzyl-1-(5,5-dimethyl-4H-1,3-thiazol-2-yl)-3-phenylurea
Molecular weight339.457
Hydrogen bond acceptor3
Hydrogen bond donor1
XlogP3.6
SynonymsCHEMBL1577289
1-benzyl-1-(5,5-dimethyl-4H-1,3-thiazol-2-yl)-3-phenylurea
AKOS022101810
STL324634
1-benzyl-1-(5,5-dimethyl-4,5-dihydro-1,3-thiazol-2-yl)-3-phenylurea
[ Show all ]
Inchi KeyCFYVRWGQGFBSSD-UHFFFAOYSA-N
Inchi IDInChI=1S/C19H21N3OS/c1-19(2)14-20-18(24-19)22(13-15-9-5-3-6-10-15)17(23)21-16-11-7-4-8-12-16/h3-12H,13-14H2,1-2H3,(H,21,23)
PubChem CID912993
ChEMBLCHEMBL1577289
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Potency18356.4 nMPubChem BioAssay data setChEMBL

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