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GPCR

NameHistamine H2 receptor
SpeciesCavia porcellus (Guinea pig)
GeneHRH2
SynonymGastric receptor I
H2R
HH2R
DiseaseN/A for non-human GPCRs
Length359
Amino acid sequenceMAFNGTVPSFCMDFTVYKVTISVILIILILVTVAGNVVVCLAVGLNRRLRSLTNCFIVSLAVTDLLLGLLVLPFSAIYQLSCKWSFSKVFCNIYTSLDVMLCTASILNLFMISLDRYCAVTDPLRYPVLITPARVAISLVFIWVISITLSFLSIHLGWNSRNETSKDNDTIVKCKVQVNEVYGLVDGLVTFYLPLLIMCITYFRIFKIAREQARRINHIGSWKAATIREHKATVTLAAVMGAFIICWFPYFTVFVYRGLKGDDAVNEVFEDVVLWLGYANSALNPILYAALNRDFRTAYHQLFCCRLASHNSHETSLRLNNSQLNRSQCQEPRWQEDKPLNLQVWSGTEVTAPQGATNR
UniProtP47747
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL2882
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL345173
Molecular formulaC17H22N6OS
IUPAC nameN-[[6-[2-(diaminomethylideneamino)-1,3-thiazol-4-yl]pyridin-2-yl]methyl]cyclohexanecarboxamide
Molecular weight358.464
Hydrogen bond acceptor5
Hydrogen bond donor3
XlogP1.6
SynonymsSCHEMBL9297825
N-[[6-[2-[(Diaminomethylene)amino]-4-thiazolyl]-2-pyridinyl]methyl]cyclohexanecarboxamide
Inchi KeyCGGSFASWEVYBHC-UHFFFAOYSA-N
Inchi IDInChI=1S/C17H22N6OS/c18-16(19)23-17-22-14(10-25-17)13-8-4-7-12(21-13)9-20-15(24)11-5-2-1-3-6-11/h4,7-8,10-11H,1-3,5-6,9H2,(H,20,24)(H4,18,19,22,23)
PubChem CID10043959
ChEMBLCHEMBL345173
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Inhibition23.0 %PMID7904648ChEMBL

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