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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	5-hydroxytryptamine receptor 2C
Species	Homo sapiens (Human)
Gene	HTR2C
Synonym	Serotonin receptor 2C serotonin 1c receptor 5-HT1C 5-HT2C 5-HT-2C 5-HT2C receptor 5-HTR2C 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled 5-hydroxytryptamine receptor 1C HTR1C 5-HT-1C [ Show all ]
Disease	Pain Sleep initiation and maintenance disorders; Primary insomnia; Schizophrenia Unspecified Depression Drug abuse Generalized anxiety disorder; Major depressive disorder Major depressive disorder Metabolic disorders Psychotic disorders Mood disorder Neurological disease Obesity Obesity; Diabetes Migraine headaches Anxiety disorder Alcohol use disorders Aggressive non-hodgkin's lymphoma [ Show all ]
Length	458
Amino acid sequence	MVNLRNAVHSFLVHLIGLLVWQCDISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSIVIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYVLRRQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNARRRKKKERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGRELNVNIYRHTNEPVIEKASDNEPGIEMQVENLELPVNPSSVVSERISSV
UniProt	P28335
Protein Data Bank	6bqg, 6bqh
GPCR-HGmod model	P28335
3D structure model	This structure is from PDB ID 6bqg.
BioLiP	BL0404805, BL0404806
Therapeutic Target Database	T83813
ChEMBL	CHEMBL225
IUPHAR	8
DrugBank	BE0004957, BE0004881, BE0000533

Ligand

Name	5-Bromotryptamine
Molecular formula	C10H11BrN2
IUPAC name	2-(5-bromo-1H-indol-3-yl)ethanamine
Molecular weight	239.116
Hydrogen bond acceptor	1
Hydrogen bond donor	2
XlogP	1.3
Synonyms	3610-42-2 AC1Q25YL CHEMBL1288717 SCHEMBL1520598 1H-Indole-3-ethanamine,5-bromo- 5-bromo-tryptamine AKOS005207534 F2113-0573 2-(5-bromo-1H-indol-3-yl)ethanamine AB03690 CGHUQJRRADEHTQ-UHFFFAOYSA-N MFCD00130169 1613AE 5-Br-T ACN-049131 CTK4H5898 ZINC403685 2-(5-BROMO-1H-INDOL-3-YL)-ETHYLAMINE BDBM50331288 K-8096 3-(2-Aminoethyl)-5-bromoindole AC1L2SH6 Oprea1_552997 1H-INDOLE-3-ETHANAMINE, 5-BROMO- 5-Bromo-1H-indole-3-ethylamine AJ-22171 EINECS 222-779-8 2-(5-BROMO-1H-INDOL-3-YL)ETHAN-1-AMINE BP-13334 KB-244764 [ Show all ]
Inchi Key	CGHUQJRRADEHTQ-UHFFFAOYSA-N
Inchi ID	InChI=1S/C10H11BrN2/c11-8-1-2-10-9(5-8)7(3-4-12)6-13-10/h1-2,5-6,13H,3-4,12H2
PubChem CID	77158
ChEMBL	CHEMBL1288717
IUPHAR	N/A
BindingDB	50331288
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	1523.0 nM	PMID8510008	BindingDB

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