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GPCR

NameProstaglandin E2 receptor EP2 subtype
SpeciesHomo sapiens (Human)
GenePTGER2
SynonymPGE receptor EP2 subtype
PGE2 receptor EP2 subtype
prostaglandin E receptor 2 (subtype EP2), 53kDa
Prostanoid EP2 receptor
Ptger-ep2
[ Show all ]
DiseaseOsteoporosis
Pulmonary arterial hypertension
Miscarriage
Medical abortion
Immune disorder
[ Show all ]
Length358
Amino acid sequenceMGNASNDSQSEDCETRQWLPPGESPAISSVMFSAGVLGNLIALALLARRWRGDVGCSAGRRSSLSLFHVLVTELVFTDLLGTCLISPVVLASYARNQTLVALAPESRACTYFAFAMTFFSLATMLMLFAMALERYLSIGHPYFYQRRVSRSGGLAVLPVIYAVSLLFCSLPLLDYGQYVQYCPGTWCFIRHGRTAYLQLYATLLLLLIVSVLACNFSVILNLIRMHRRSRRSRCGPSLGSGRGGPGARRRGERVSMAEETDHLILLAIMTITFAVCSLPFTIFAYMNETSSRKEKWDLQALRFLSINSIIDPWVFAILRPPVLRLMRSVLCCRISLRTQDATQTSCSTQSDASKQADL
UniProtP43116
Protein Data BankN/A
GPCR-HGmod modelP43116
3D structure modelThis predicted structure model is from GPCR-EXP P43116.
BioLiPN/A
Therapeutic Target DatabaseT38529
ChEMBLCHEMBL1881
IUPHAR341
DrugBankBE0000368

Ligand

Nameindomethacin
Molecular formulaC19H16ClNO4
IUPAC name2-[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid
Molecular weight357.79
Hydrogen bond acceptor4
Hydrogen bond donor1
XlogP4.3
SynonymsLausit
Indomet 140
Metacen
Indometacine
MLS000069402
[ Show all ]
Inchi KeyCGIGDMFJXJATDK-UHFFFAOYSA-N
Inchi IDInChI=1S/C19H16ClNO4/c1-11-15(10-18(22)23)16-9-14(25-2)7-8-17(16)21(11)19(24)12-3-5-13(20)6-4-12/h3-9H,10H2,1-2H3,(H,22,23)
PubChem CID3715
ChEMBLCHEMBL6
IUPHAR1909
BindingDB17638
DrugBankDB00328

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Ki7.0 nMPMID10411562PDSP,BindingDB
Ki18.0 nMPMID10411562, PMID11160644PDSP,BindingDB
Ki19.8 nMPMID10411562, PMID11160644PDSP,BindingDB
Ki21.0 nMPMID10411562PDSP,BindingDB
Ki27.0 nMPMID10411562, PMID11160644PDSP,BindingDB
Ki57.0 nMPMID10411562PDSP,BindingDB
Ki100.0 nMPMID10411562PDSP,BindingDB

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