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GPCR

NameHistamine H2 receptor
SpeciesCavia porcellus (Guinea pig)
GeneHRH2
SynonymGastric receptor I
H2R
HH2R
DiseaseN/A for non-human GPCRs
Length359
Amino acid sequenceMAFNGTVPSFCMDFTVYKVTISVILIILILVTVAGNVVVCLAVGLNRRLRSLTNCFIVSLAVTDLLLGLLVLPFSAIYQLSCKWSFSKVFCNIYTSLDVMLCTASILNLFMISLDRYCAVTDPLRYPVLITPARVAISLVFIWVISITLSFLSIHLGWNSRNETSKDNDTIVKCKVQVNEVYGLVDGLVTFYLPLLIMCITYFRIFKIAREQARRINHIGSWKAATIREHKATVTLAAVMGAFIICWFPYFTVFVYRGLKGDDAVNEVFEDVVLWLGYANSALNPILYAALNRDFRTAYHQLFCCRLASHNSHETSLRLNNSQLNRSQCQEPRWQEDKPLNLQVWSGTEVTAPQGATNR
UniProtP47747
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL2882
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL323568
Molecular formulaC20H23N5O3S
IUPAC nameN-[[5-[2-[[N'-[(2-ethoxyphenyl)methyl]carbamimidoyl]amino]-1,3-thiazol-4-yl]furan-2-yl]methyl]acetamide
Molecular weight413.496
Hydrogen bond acceptor6
Hydrogen bond donor3
XlogP1.9
Synonyms2-[2-(2-Ethoxybenzyl)guanidino]-4-[5-(acetylaminomethyl)-2-furyl]thiazole
SCHEMBL9264346
Inchi KeyCGMDGCZTCFJCNC-UHFFFAOYSA-N
Inchi IDInChI=1S/C20H23N5O3S/c1-3-27-17-7-5-4-6-14(17)10-23-19(21)25-20-24-16(12-29-20)18-9-8-15(28-18)11-22-13(2)26/h4-9,12H,3,10-11H2,1-2H3,(H,22,26)(H3,21,23,24,25)
PubChem CID10341667
ChEMBLCHEMBL323568
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Inhibition42.0 %PMID10425101ChEMBL

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