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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Prostaglandin E2 receptor EP2 subtype
Species	Homo sapiens (Human)
Gene	PTGER2
Synonym	PGE receptor EP2 subtype PGE2 receptor EP2 subtype prostaglandin E receptor 2 (subtype EP2), 53kDa Prostanoid EP2 receptor Ptger-ep2 EP2 receptor [ Show all ]
Disease	Osteoporosis Pulmonary arterial hypertension Miscarriage Medical abortion Immune disorder Glaucoma Solid tumours Endometriosis Diabetic foot ulcer Cancer [ Show all ]
Length	358
Amino acid sequence	MGNASNDSQSEDCETRQWLPPGESPAISSVMFSAGVLGNLIALALLARRWRGDVGCSAGRRSSLSLFHVLVTELVFTDLLGTCLISPVVLASYARNQTLVALAPESRACTYFAFAMTFFSLATMLMLFAMALERYLSIGHPYFYQRRVSRSGGLAVLPVIYAVSLLFCSLPLLDYGQYVQYCPGTWCFIRHGRTAYLQLYATLLLLLIVSVLACNFSVILNLIRMHRRSRRSRCGPSLGSGRGGPGARRRGERVSMAEETDHLILLAIMTITFAVCSLPFTIFAYMNETSSRKEKWDLQALRFLSINSIIDPWVFAILRPPVLRLMRSVLCCRISLRTQDATQTSCSTQSDASKQADL
UniProt	P43116
Protein Data Bank	N/A
GPCR-HGmod model	P43116
3D structure model	This predicted structure model is from GPCR-EXP P43116.
BioLiP	N/A
Therapeutic Target Database	T38529
ChEMBL	CHEMBL1881
IUPHAR	341
DrugBank	BE0000368

Ligand

Name	CHEMBL3260419
Molecular formula	C19H16O4
IUPAC name	5-methyl-4-[(4-phenylphenoxy)methyl]furan-2-carboxylic acid
Molecular weight	308.333
Hydrogen bond acceptor	4
Hydrogen bond donor	1
XlogP	4.3
Synonyms	Oprea1_438686 AKOS003598613 SMSF0012269 CBMicro_007272 Oprea1_497289 BDBM50012550 ZINC5360995 4-(Biphenyl-4-yloxymethyl)-5-methyl-furan-2-carboxylic acid CHBRWBFWESIPKH-UHFFFAOYSA-N MolPort-001-016-073 AC1LG0LI SCHEMBL1756460 BIM-0007300.P001 5-methyl-4-[(4-phenylphenoxy)methyl]furan-2-carboxylic acid [ Show all ]
Inchi Key	CHBRWBFWESIPKH-UHFFFAOYSA-N
Inchi ID	InChI=1S/C19H16O4/c1-13-16(11-18(23-13)19(20)21)12-22-17-9-7-15(8-10-17)14-5-3-2-4-6-14/h2-11H,12H2,1H3,(H,20,21)
PubChem CID	786859
ChEMBL	CHEMBL3260419
IUPHAR	N/A
BindingDB	50012550
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Inhibition	95.0 %	PMID24703233	ChEMBL

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