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GPCR

NameG-protein coupled receptor homolog US28
SpeciesHuman cytomegalovirus (strain AD169) (HHV-5)
GeneUS28
SynonymHHRF3
DiseaseN/A for non-human GPCRs
Length354
Amino acid sequenceMTPTTTTAELTTEFDYDEDATPCVFTDVLNQSKPVTLFLYGVVFLFGSIGNFLVIFTITWRRRIQCSGDVYFINLAAADLLFVCTLPLWMQYLLDHNSLASVPCTLLTACFYVAMFASLCFITEIALDRYYAIVYMRYRPVKQACLFSIFWWIFAVIIAIPHFMVVTKKDNQCMTDYDYLEVSYPIILNVELMLGAFVIPLSVISYCYYRISRIVAVSQSRHKGRIVRVLIAVVLVFIIFWLPYHLTLFVDTLKLLKWISSSCEFERSLKRALILTESLAFCHCCLNPLLYVFVGTKFRQELHCLLAEFRQRLFSRDVSWYHSMSFSRRSSPSRRETSSDTLSDEVCRVSQIIP
UniProtP69332
Protein Data Bank4xt1
GPCR-HGmod modelN/A
3D structure modelThis structure is from PDB ID 4xt1.
BioLiPBL0309402,BL0309403
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL4259
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL198553
Molecular formulaC28H32ClNO
IUPAC name4-(4-chlorophenyl)-1-[4-(2-methylphenyl)-4-phenylbutyl]piperidin-4-ol
Molecular weight434.02
Hydrogen bond acceptor2
Hydrogen bond donor1
XlogP6.5
SynonymsBDBM50027210
4-(4-Chloro-phenyl)-1-(4-phenyl-4-o-tolyl-butyl)-piperidin-4-ol
Inchi KeyYSSUEOYNEQTLNV-UHFFFAOYSA-N
Inchi IDInChI=1S/C28H32ClNO/c1-22-8-5-6-11-26(22)27(23-9-3-2-4-10-23)12-7-19-30-20-17-28(31,18-21-30)24-13-15-25(29)16-14-24/h2-6,8-11,13-16,27,31H,7,12,17-21H2,1H3
PubChem CID11719018
ChEMBLCHEMBL198553
IUPHARN/A
BindingDB50027210
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has a partition coefficient log P greater than 5.

Experimental Data

ParameterValueReferenceDatabase source
EC509800.0 nMPMID16190772BindingDB,ChEMBL
IC505500.0 nMPMID16190772BindingDB,ChEMBL

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