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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Muscarinic acetylcholine receptor M4
Species	Gallus gallus (Chicken)
Gene	CHRM4
Synonym	N/A
Disease	N/A for non-human GPCRs
Length	490
Amino acid sequence	MHNLSAQPWQAKMANLTYDNVTLSNRSEVAIQPPTNYKTVELVFIATVTGSLSLVTVVGNILVMLSIKVNRQLQTVNNYFLFSLACADLIIGVFSMNLYTVYIIKGYWPLGAVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPARRTTKMAGLMIAAAWILSFILWAPAILFWQFIVGKRTVHERECYIQFLSNPAVTFGTAIAAFYLPVVIMTVLYIHISLASRSRVRRHKPESRKERKGKSLSFFKAPPVKQNNNNSPKRAVEVKEEVRNGKVDDQPSAQTEATGQQEEKETSNESSTVSMTQTTKDKPTTEILPAGQGQSPAHPRVNPTSKWSKIKIVTKQTGTESVTAIEIVPAKAGASDHNSLSNSRPANVARKFASIARSQVRKKRQMAAREKKVTRTIFAILLAFILTWTPYNVMVLINTFCETCVPETVWSIGYWLCYVNSTINPACYALCNATFKKTFKHLLMCQYRNIGTAR
UniProt	P17200
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	N/A
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	biperiden
Molecular formula	C21H29NO
IUPAC name	1-(2-bicyclo[2.2.1]hept-5-enyl)-1-phenyl-3-piperidin-1-ylpropan-1-ol
Molecular weight	311.469
Hydrogen bond acceptor	2
Hydrogen bond donor	1
XlogP	4.3
Synonyms	Akinophyl (Salt/Mix) BDBM50240680 Biperiden lactate Biperideno [INN-Spanish] CHEBI:3112 EINECS 208-184-6 NCGC00182965-01 1-(Bicyclo(2.2.1)hept-5-en-2alpha-yl)-1-phenyl-3-piperidinopropanol PDSP2_000808 1-Piperidinepropanol, alpha-bicyclo(2.2.1)hept-5-en-2-yl-alpha-phenyl- SPBio_002344 5-Norbornene-2-methanol, alpha-phenyl-alpha-(2-piperidinoethyl)- alpha-5-Norbornen-2-yl-alpha-phenyl-1-piperidinepropanol Bipariden Biperiden [USP:INN:BAN:JAN] Biperidine D00779 HSDB 7639 .alpha.-(Bicyclo(2.2.1)hept-5-en-2-yl)-.alpha.-phenyl-1-piperidino propanol NCGC00182965-04 1-Bicyclo[2.2.1]hept-5-en-2-yl-1-phenyl-3-(1-piperidinyl)-1-propanol # Prestwick1_000502 3-Piperidino-1-phenyl-1-bicyclo(2.2.1)hepten-(5)-yl-propanol-(1) UNII-0FRP6G56LD AN-45471 Biperiden HCl Biperidene [INN-French] C07941 DB00810 L001222 1-(5-bicyclo[2.2.1]hept-2-enyl)-1-phenyl-3-(1-piperidyl)propan-1-ol NSC759145 1-Piperidinepropanol, .alpha.-bicyclo[2.2.1]hept-5-en-2-yl-.alpha.-phenyl-, hydrochloride SCHEMBL20229360 5-20-02-00242 (Beilstein Handbook Reference) Akineton (TN) AKOS016008819 Beperiden Biperiden [USAN:BAN:INN:JAN] Biperidenum CHEMBL1101 GTPL7128 NCGC00182965-02 1-(bicyclo[2.2.1]hept-5-en-2-yl)-1-phenyl-3-(piperidin-1-yl)propan-1-ol Pharmakon1600-01505514 1-{bicyclo[2.2.1]hept-5-en-2-yl}-1-phenyl-3-(piperidin-1-yl)propan-1-ol SR-05000001649 alpha-Bicyclo(2.2.1)hept-5-en-2-yl-alpha-phenyl-1-piperidinepropanol Biperidene BRD-A00546892-001-01-8 D0B4TN HY-13204A .alpha.-5-Norbornen-2-yl-.alpha.-phenyl-1-piperidinepropanol NCIOpen2_009564 1-Piperidinepropanol, .alpha.-5-norbornen-2-yl-.alpha.-phenyl- Prestwick2_000502 3-Piperidino-1-phenyl-1-bicyclo(2.2.1)hepten-(5)-yl-propanol-(1) [German] VA10409 AC1L1DJT AX8116739 Biperiden hydrochloride Biperideno CCG-213474 DTXSID6022680 LS-116068 1-(5-bicyclo[2.2.1]hept-2-enyl)-1-phenyl-3-piperidin-1-ylpropan-1-ol PDSP1_000821 1-PIPERIDINEPROPANOL, alpha-5-NORBORNEN-2-YL-alpha-PHENYL- SCHEMBL34957 5-Norbornene-2-methanol, .alpha.-phenyl-.alpha.-(2-piperidinoethyl)- Akinophyl alpha-(Bicyclo(2.2.1)hept-5-en-2-yl)-alpha-phenyl-1-piperidino propanol Bicyclo[2.2.1]hept-5-ene-2-methanol, .alpha.-phenyl-.alpha.-[2-(1-piperidinyl)ethyl]- Biperiden [USAN:INN:BAN:JAN] Biperidenum [INN-Latin] CS-1797 HMS2093N17 NCGC00182965-03 1-Bicycloheptenyl-1-phenyl-3-piperidino-propanol-1 Prestwick0_000502 1235-82-1 (hydrochloride) SR-05000001649-1 514-65-8 alpha-bicyclo[2.2.1]hept-5-en-2-yl-alpha-phenyl-1-piperidinepropanol Biperiden (JAN/USP/INN) Biperidene hydrochloride BRN 0290038 KL 373 0FRP6G56LD NSC-759145 1-Piperidinepropanol, .alpha.-bicyclo[2.2.1]hept-5-en-2-yl-.alpha.-phenyl- SBI-0206797.P001 3-Piperidino-1-phenyl-1-bicycloheptenyl-1-propanol YSXKPIUOCJLQIE-UHFFFAOYSA-N Akineton [ Show all ]
Inchi Key	YSXKPIUOCJLQIE-UHFFFAOYSA-N
Inchi ID	InChI=1S/C21H29NO/c23-21(19-7-3-1-4-8-19,11-14-22-12-5-2-6-13-22)20-16-17-9-10-18(20)15-17/h1,3-4,7-10,17-18,20,23H,2,5-6,11-16H2
PubChem CID	2381
ChEMBL	N/A
IUPHAR	7128
BindingDB	50240680
DrugBank	DB00810
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	1.7 nM	PMID2250662	BindingDB

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