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GPCR

Name	fMet-Leu-Phe receptor
Species	Homo sapiens (Human)
Gene	FPR1
Synonym	NFPR N-formylpeptide chemoattractant receptor N-formyl peptide receptor FPR1 FPR formyl peptide receptor 1 fMLP receptor fMLF-R [ Show all ]
Disease	Inflammatory disease Peptic ulcer
Length	350
Amino acid sequence	METNSSLPTNISGGTPAVSAGYLFLDIITYLVFAVTFVLGVLGNGLVIWVAGFRMTHTVTTISYLNLAVADFCFTSTLPFFMVRKAMGGHWPFGWFLCKFVFTIVDINLFGSVFLIALIALDRCVCVLHPVWTQNHRTVSLAKKVIIGPWVMALLLTLPVIIRVTTVPGKTGTVACTFNFSPWTNDPKERINVAVAMLTVRGIIRFIIGFSAPMSIVAVSYGLIATKIHKQGLIKSSRPLRVLSFVAAAFFLCWSPYQVVALIATVRIRELLQGMYKEIGIAVDVTSALAFFNSCLNPMLYVFMGQDFRERLIHALPASLERALTEDSTQTSDTATNSTLPSAEVELQAK
UniProt	P21462
Protein Data Bank	N/A
GPCR-HGmod model	P21462
3D structure model	This predicted structure model is from GPCR-EXP P21462.
BioLiP	N/A
Therapeutic Target Database	T87831
ChEMBL	CHEMBL3359
IUPHAR	222
DrugBank	BE0000995

Ligand

Name	CHEMBL2391438
Molecular formula	C24H20BrN3O2
IUPAC name	N-(4-bromophenyl)-2-[3-methyl-5-(naphthalen-1-ylmethyl)-6-oxopyridazin-1-yl]acetamide
Molecular weight	462.347
Hydrogen bond acceptor	3
Hydrogen bond donor	1
XlogP	4.6
Synonyms	BDBM50435905 SCHEMBL18015878
Inchi Key	YSXUKSMIDAEZEQ-UHFFFAOYSA-N
Inchi ID	InChI=1S/C24H20BrN3O2/c1-16-13-19(14-18-7-4-6-17-5-2-3-8-22(17)18)24(30)28(27-16)15-23(29)26-21-11-9-20(25)10-12-21/h2-13H,14-15H2,1H3,(H,26,29)
PubChem CID	71699061
ChEMBL	CHEMBL2391438
IUPHAR	N/A
BindingDB	50435905
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	13800.0 nM	PMID23685570	ChEMBL
Efficacy	20.0 %	PMID23685570	ChEMBL

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