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Name | Metabotropic glutamate receptor 2 |
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Species | Rattus norvegicus (Rat) |
Gene | Grm2 |
Synonym | glutamate receptor GPRC1B metabotropic glutamate receptor 2 mGlu2 receptor mGluR2 |
Disease | N/A for non-human GPCRs |
Length | 872 |
Amino acid sequence | MESLLGFLALLLLWGAVAEGPAKKVLTLEGDLVLGGLFPVHQKGGPAEECGPVNEHRGIQRLEAMLFALDRINRDPHLLPGVRLGAHILDSCSKDTHALEQALDFVRASLSRGADGSRHICPDGSYATHSDAPTAVTGVIGGSYSDVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDYFARTVPPDFFQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFELEARARNICVATSEKVGRAMSRAAFEGVVRALLQKPSARVAVLFTRSEDARELLAATQRLNASFTWVASDGWGALESVVAGSERAAEGAITIELASYPISDFASYFQSLDPWNNSRNPWFREFWEERFHCSFRQRDCAAHSLRAVPFEQESKIMFVVNAVYAMAHALHNMHRALCPNTTHLCDAMRPVNGRRLYKDFVLNVKFDAPFRPADTDDEVRFDRFGDGIGRYNIFTYLRAGSGRYRYQKVGYWAEGLTLDTSFIPWASPSAGPLPASRCSEPCLQNEVKSVQPGEVCCWLCIPCQPYEYRLDEFTCADCGLGYWPNASLTGCFELPQEYIRWGDAWAVGPVTIACLGALATLFVLGVFVRHNATPVVKASGRELCYILLGGVFLCYCMTFVFIAKPSTAVCTLRRLGLGTAFSVCYSALLTKTNRIARIFGGAREGAQRPRFISPASQVAICLALISGQLLIVAAWLVVEAPGTGKETAPERREVVTLRCNHRDASMLGSLAYNVLLIALCTLYAFKTRKCPENFNEAKFIGFTMYTTCIIWLAFLPIFYVTSSDYRVQTTTMCVSVSLSGSVVLGCLFAPKLHIILFQPQKNVVSHRAPTSRFGSAAPRASANLGQGSGSQFVPTVCNGREVVDSTTSSL |
UniProt | P31421 |
Protein Data Bank | N/A |
GPCR-HGmod model | N/A |
3D structure model | No available structures or models |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL2851 |
IUPHAR | 290 |
DrugBank | N/A |
Name | CHEMBL256424 |
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Molecular formula | C29H24FN5O2 |
IUPAC name | 8-[2-(4-fluorophenyl)ethynyl]-7-[2-hydroxyethyl(methyl)amino]-4-(3-imidazol-1-ylphenyl)-1,3-dihydro-1,5-benzodiazepin-2-one |
Molecular weight | 493.542 |
Hydrogen bond acceptor | 6 |
Hydrogen bond donor | 2 |
XlogP | 3.7 |
Synonyms | BDBM50372874 SCHEMBL7172578 |
Inchi Key | CHIPHPDGPBIINM-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C29H24FN5O2/c1-34(13-14-36)28-17-27-26(16-22(28)8-5-20-6-9-23(30)10-7-20)33-29(37)18-25(32-27)21-3-2-4-24(15-21)35-12-11-31-19-35/h2-4,6-7,9-12,15-17,19,36H,13-14,18H2,1H3,(H,33,37) |
PubChem CID | 22448874 |
ChEMBL | CHEMBL256424 |
IUPHAR | N/A |
BindingDB | 50372874 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
IC50 | 140.0 nM | PMID18096387 | ChEMBL |
zhanglabzhanggroup.org | (734) 647-1549 | 100 Washtenaw Avenue, Ann Arbor, MI 48109-2218