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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	Sphingosine 1-phosphate receptor 4
Species	Homo sapiens (Human)
Gene	S1PR4
Synonym	S1P4 receptor S1P4 S1P receptor Edg-6 S1P receptor 4 endothelial differentiation, G protein-coupled receptor 6 Endothelial differentiation G-protein coupled receptor 6 edg6 Sphingosine 1-phosphate receptor Edg-6 [ Show all ]
Disease	N/A
Length	384
Amino acid sequence	MNATGTPVAPESCQQLAAGGHSRLIVLHYNHSGRLAGRGGPEDGGLGALRGLSVAASCLVVLENLLVLAAITSHMRSRRWVYYCLVNITLSDLLTGAAYLANVLLSGARTFRLAPAQWFLREGLLFTALAASTFSLLFTAGERFATMVRPVAESGATKTSRVYGFIGLCWLLAALLGMLPLLGWNCLCAFDRCSSLLPLYSKRYILFCLVIFAGVLATIMGLYGAIFRLVQASGQKAPRPAARRKARRLLKTVLMILLAFLVCWGPLFGLLLADVFGSNLWAQEYLRGMDWILALAVLNSAVNPIIYSFRSREVCRAVLSFLCCGCLRLGMRGPGDCLARAVEAHSGASTTDSSLRPRDSFRGSRSLSFRMREPLSSISSVRSI
UniProt	O95977
Protein Data Bank	N/A
GPCR-HGmod model	O95977
3D structure model	This predicted structure model is from GPCR-EXP O95977.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3230
IUPHAR	278
DrugBank	N/A

Ligand

Name	CHEMBL1779914
Molecular formula	C17H15NO2S
IUPAC name	N-(2,6-dimethylphenyl)-5-thiophen-2-ylfuran-2-carboxamide
Molecular weight	297.372
Hydrogen bond acceptor	3
Hydrogen bond donor	1
XlogP	4.3
Synonyms	N-(2,6-dimethylphenyl)-5-(thiophen-2-yl)furan-2-carboxamide BDBM50344809
Inchi Key	AFJMCYKWIVQVNW-UHFFFAOYSA-N
Inchi ID	InChI=1S/C17H15NO2S/c1-11-5-3-6-12(2)16(11)18-17(19)14-9-8-13(20-14)15-7-4-10-21-15/h3-10H,1-2H3,(H,18,19)
PubChem CID	54586463
ChEMBL	CHEMBL1779914
IUPHAR	N/A
BindingDB	50344809
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	118.0 nM	PMID21570287	BindingDB,ChEMBL

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