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Name | Hydroxycarboxylic acid receptor 2 |
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Species | Homo sapiens (Human) |
Gene | HCAR2 |
Synonym | G-protein coupled receptor HM74A G-protein coupled receptor 109A PUMAG Nicotinic acid receptor HCA2 receptor [ Show all ] |
Disease | Hyperlipidaemia Acute ischemic stroke Arteriosclerosis Atherosclerosis Cardiovascular disorder [ Show all ] |
Length | 363 |
Amino acid sequence | MNRHHLQDHFLEIDKKNCCVFRDDFIVKVLPPVLGLEFIFGLLGNGLALWIFCFHLKSWKSSRIFLFNLAVADFLLIICLPFLMDNYVRRWDWKFGDIPCRLMLFMLAMNRQGSIIFLTVVAVDRYFRVVHPHHALNKISNRTAAIISCLLWGITIGLTVHLLKKKMPIQNGGANLCSSFSICHTFQWHEAMFLLEFFLPLGIILFCSARIIWSLRQRQMDRHAKIKRAITFIMVVAIVFVICFLPSVVVRIRIFWLLHTSGTQNCEVYRSVDLAFFITLSFTYMNSMLDPVVYYFSSPSFPNFFSTLINRCLQRKMTGEPDNNRSTSVELTGDPNKTRGAPEALMANSGEPWSPSYLGPTSP |
UniProt | Q8TDS4 |
Protein Data Bank | N/A |
GPCR-HGmod model | Q8TDS4 |
3D structure model | This predicted structure model is from GPCR-EXP Q8TDS4. |
BioLiP | N/A |
Therapeutic Target Database | T00864 |
ChEMBL | CHEMBL3785 |
IUPHAR | 312 |
DrugBank | BE0000635 |
Name | 5-isopropyl-1H-pyrazole-3-carboxylic acid |
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Molecular formula | C7H10N2O2 |
IUPAC name | 5-propan-2-yl-1H-pyrazole-3-carboxylic acid |
Molecular weight | 154.169 |
Hydrogen bond acceptor | 3 |
Hydrogen bond donor | 2 |
XlogP | 1.2 |
Synonyms | 92933-47-6 5-Isopropyl-2H-pyrazole-3-carboxylic acid 3-isopropyl-1H-pyrazole-5-carboxylic acid 5-ISOPROPYLPYRAZOLE-3-CARBOXYLIC ACID 3-(propan-2-yl)-1H-pyrazole-5-carboxylic acid [ Show all ] |
Inchi Key | CHWXKAHFWLSLOQ-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C7H10N2O2/c1-4(2)5-3-6(7(10)11)9-8-5/h3-4H,1-2H3,(H,8,9)(H,10,11) |
PubChem CID | 776421 |
ChEMBL | CHEMBL238002 |
IUPHAR | N/A |
BindingDB | 50211363 |
DrugBank | N/A |
Structure | ![]() |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
EC50 | <1000.0 nM | PMID17804224 | ChEMBL |
EC50 | 109.65 nM | PMID17804224 | ChEMBL |
EC50 | 110.0 nM | PMID17804224 | BindingDB |
EC50 | 8300.0 nM | PMID17588745 | BindingDB,ChEMBL |
Efficacy | 95.0 % | PMID17804224 | ChEMBL |
IC50 | 2600.0 nM | PMID17452318 | BindingDB,ChEMBL |
Inhibition | 98.0 % | PMID17452318 | ChEMBL |
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