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Name | Beta-1 adrenergic receptor |
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Species | Homo sapiens (Human) |
Gene | ADRB1 |
Synonym | Adrenergic receptor beta 1 Adrb-1 ADRB1R adrenergic receptor beta 1-AR [ Show all ] |
Disease | Heart failure; Cardiogenic shock Heart failure Glaucoma Diabetes Coronary artery disease [ Show all ] |
Length | 477 |
Amino acid sequence | MGAGVLVLGASEPGNLSSAAPLPDGAATAARLLVPASPPASLLPPASESPEPLSQQWTAGMGLLMALIVLLIVAGNVLVIVAIAKTPRLQTLTNLFIMSLASADLVMGLLVVPFGATIVVWGRWEYGSFFCELWTSVDVLCVTASIETLCVIALDRYLAITSPFRYQSLLTRARARGLVCTVWAISALVSFLPILMHWWRAESDEARRCYNDPKCCDFVTNRAYAIASSVVSFYVPLCIMAFVYLRVFREAQKQVKKIDSCERRFLGGPARPPSPSPSPVPAPAPPPGPPRPAAAAATAPLANGRAGKRRPSRLVALREQKALKTLGIIMGVFTLCWLPFFLANVVKAFHRELVPDRLFVFFNWLGYANSAFNPIIYCRSPDFRKAFQRLLCCARRAARRRHATHGDRPRASGCLARPGPPPSPGAASDDDDDDVVGATPPARLLEPWAGCNGGAAADSDSSLDEPCRPGFASESKV |
UniProt | P08588 |
Protein Data Bank | N/A |
GPCR-HGmod model | P08588 |
3D structure model | This predicted structure model is from GPCR-EXP P08588. |
BioLiP | N/A |
Therapeutic Target Database | T44068 |
ChEMBL | CHEMBL213 |
IUPHAR | 28 |
DrugBank | BE0000172 |
Name | sotalol |
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Molecular formula | C12H20N2O3S |
IUPAC name | N-[4-[1-hydroxy-2-(propan-2-ylamino)ethyl]phenyl]methanesulfonamide |
Molecular weight | 272.363 |
Hydrogen bond acceptor | 5 |
Hydrogen bond donor | 3 |
XlogP | 0.2 |
Synonyms | BRD-A33168282-003-03-2 CCG-205132 D08525 DSSTox_RID_77096 LS-90249 [ Show all ] |
Inchi Key | ZBMZVLHSJCTVON-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C12H20N2O3S/c1-9(2)13-8-12(15)10-4-6-11(7-5-10)14-18(3,16)17/h4-7,9,12-15H,8H2,1-3H3 |
PubChem CID | 5253 |
ChEMBL | CHEMBL471 |
IUPHAR | N/A |
BindingDB | 25762 |
DrugBank | DB00489 |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
N/A | N/A | DrugBank | |
IC50 | 1443.4 nM | DrugMatrix in vitro pharmacology data | ChEMBL |
IC50 | 8900.0 nM | PMID1976812 | BindingDB,ChEMBL |
IC50 | 9000.0 nM | PMID2319556, PMID1347318 | BindingDB,ChEMBL |
Kd | 1698.0 nM | PMID15655528 | BindingDB |
Ki | 833.5 nM | DrugMatrix in vitro pharmacology data | ChEMBL |
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