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GPCR

NameThyrotropin-releasing hormone receptor
SpeciesHomo sapiens (Human)
GeneTRHR
SynonymThyroliberin receptor
TRH receptor
TRH-R
TRH-R1
TRH1 receptor
DiseaseUnspecified
Pain
Neurodegenerative disease
Endocrine disease
Cognitive disorders
[ Show all ]
Length398
Amino acid sequenceMENETVSELNQTQLQPRAVVALEYQVVTILLVLIICGLGIVGNIMVVLVVMRTKHMRTPTNCYLVSLAVADLMVLVAAGLPNITDSIYGSWVYGYVGCLCITYLQYLGINASSCSITAFTIERYIAICHPIKAQFLCTFSRAKKIIIFVWAFTSLYCMLWFFLLDLNISTYKDAIVISCGYKISRNYYSPIYLMDFGVFYVVPMILATVLYGFIARILFLNPIPSDPKENSKTWKNDSTHQNTNLNVNTSNRCFNSTVSSRKQVTKMLAVVVILFALLWMPYRTLVVVNSFLSSPFQENWFLLFCRICIYLNSAINPVIYNLMSQKFRAAFRKLCNCKQKPTEKPANYSVALNYSVIKESDHFSTELDDITVTDTYLSATKVSFDDTCLASEVSFSQS
UniProtP34981
Protein Data BankN/A
GPCR-HGmod modelP34981
3D structure modelThis predicted structure model is from GPCR-EXP P34981.
BioLiPN/A
Therapeutic Target DatabaseT77796
ChEMBLCHEMBL1810
IUPHAR363
DrugBankBE0008659

Ligand

NameMLS001033855
Molecular formulaC13H13BrFN3S
IUPAC nameN-(3,4-dihydro-2H-pyrrol-5-yl)-4-(4-fluorophenyl)-1,3-thiazol-2-amine;hydrobromide
Molecular weight342.23
Hydrogen bond acceptor4
Hydrogen bond donor2
XlogPNone
SynonymsSMR000385723
CHEMBL1351045
Inchi KeyCIGSMHNBASYCPI-UHFFFAOYSA-N
Inchi IDInChI=1S/C13H12FN3S.BrH/c14-10-5-3-9(4-6-10)11-8-18-13(16-11)17-12-2-1-7-15-12;/h3-6,8H,1-2,7H2,(H,15,16,17);1H
PubChem CID16196826
ChEMBLCHEMBL1351045
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessPartition coefficient log P of this ligand is not available.

Experimental Data

ParameterValueReferenceDatabase source
Potency2909.3 nMPubChem BioAssay data setChEMBL

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