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●BioLiP ●E. coli ●GLASS ●GPCR-HGmod ●GPCR-RD ●GPCR-EXP ●Tara-3D ●TM-fold ●DECOYS ●POTENTIAL ●RW/RWplus ●EvoEF ●HPSF ●THE-DB ●ADDRESS ●Alpaca-Antibody ●CASP7 ●CASP8 ●CASP9 ●CASP10 ●CASP11 ●CASP12 ●CASP13 ●CASP14
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Name | P2Y purinoceptor 2 |
---|---|
Species | Cricetulus griseus (Chinese hamster) |
Gene | P2RY2 |
Synonym | P2Y2 |
Disease | N/A for non-human GPCRs |
Length | 166 |
Amino acid sequence | VHRCLGVLRPLHSLRWGRARYARRVAAVVWVLVLACQAPVLYFVTTSVRGTRITCHDTSARELFSHFVAYSSVMLSLLFAVPFSVILVCYVLMARRLLKPAYGTTGGLPRAKRKSVRTIALVLAVFTLCFLPFHVTRTLYYSFRSLDLSCHTLNAINMAYKITRPL |
UniProt | P58825 |
Protein Data Bank | N/A |
GPCR-HGmod model | N/A |
3D structure model | No available structures or models |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | N/A |
IUPHAR | N/A |
DrugBank | N/A |
Name | theophylline |
---|---|
Molecular formula | C7H8N4O2 |
IUPAC name | 1,3-dimethyl-7H-purine-2,6-dione |
Molecular weight | 180.167 |
Hydrogen bond acceptor | 3 |
Hydrogen bond donor | 1 |
XlogP | 0.0 |
Synonyms | KBioSS_001518 Prestwick0_000820 LASMA Pro-vent MLS000069390 Theostat 80 [ Show all ]Q-201819 N1442 Unicontin CR Dimethylxanthine NCGC00018117-07 Uniphylline Duraphyllin NCGC00018117-15 Xanthium Elixophyllin (TN) NCGC00022112-04 F2173-0145 NCGC00254040-01 HMS2233E16 NSC2066 IDI1_000203 Parkophyllin BRD-K97799481-002-03-6 Tefamin 3,7-dihydro-1,3-dimethyl-1H- purine-2,6-dione Theophylline, 99+%, anhydrous BSPBio_000945 Teofyllamin 6461-EP2272835A1 Theophylline-SR CHEBI:28177 Theo 24 6461-EP2298305A1 component of Hecadrol (Salt/Mix) Theo-Dur-Sprinkle 6461-EP2314590A1 Quibron-t (TN) component of Slo-phyllin GG (Salt/Mix) Theochron AB00052106-22 SC-05534 ConstantT Theoclear-80 Accurbron SloPhyllin Theodur G (TN) Afonilum Somophyllin-DF 0I55128JYK Theolixir ARONIS25346 Spectrum3_000672 1,3-Dimethyl-3,7-dihydro-1H-purine-2,6-dione Theophyllin BDBM82053 SR-01000075195-5 111079-49-3 Theophylline anhydrous PDSP2_001002 KSC491S8L Prestwick1_000873 LS-241 Pulmidur MLS004491910 Tox21_110827 NCGC00018117-02 Unilong DSSTox_CID_1336 NCGC00018117-10 von ct, theo EINECS 200-385-7 NCGC00018117-18 ZFXYFBGIUFBOJW-UHFFFAOYSA-N Elixophylline NCGC00022112-08 GS 2591A NE11194 HMS500K05 Nuelin S.A KBio2_001518 Theophylline melting point standard, Pharmaceutical Secondary Standard; Certified Reference Material Bronchoretard Telbans Dry Syrup 46157-00-0 Theophylline, anhydrous, >=99%, powder C7H8N4O2 Teosona 6461-EP2280006A1 Theospan Choledyl SA Theo-11 6461-EP2301937A1 Quibron T SR component of Primatene (Salt/Mix) Theo24 Respicur component of Theo-Organidin Theoclear AB00052106_25 SCHEMBL8312163 ct, theo von Theodel Aerolate SMR003435989 Theokin AKOS000120961 SPBio_000823 1,3-dimethyl-1H-purine-2,6(3H,7H)-dione Theopek Asmax Spectrum_001038 1,3-Dimethyl-6-hydroxy-1,3-dihydro-2H-purin-2-one Theophylline (anhydrous) Bilordyl Sustaire 1H-Purine-2,6-dione, 3,7-dihydro-1,3-dimethyl- KBio3_001583 Physpa Labophylline Prestwick3_000820 Medaphyllin Purine-2,3H)-dione, 1,3-dimethyl- MolPort-001-737-342 Tox21_300028 DB00277 NCGC00018117-05 Uniphyllin DTXSID5021336 NCGC00018117-13 Xanthine, 1,3-dimethyl- Elixomin NCGC00018117-23 Euphylline NCGC00022112-11 HMS2089A06 NSC-2066 Hylate Opera_ID_76 T-Phyl 2,6-Dihydroxy-1,3-dimethylpurine Theophylline solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material Bronkotabs Teofilina 58-55-9 Theophylline, European Pharmacopoeia (EP) Reference Standard CCRIS 4729 Theal tabl. 6461-EP2286811A1 component of Dicurin Procaine Theo-DS 6461-EP2308562A2 Quibron TSR component of Quibron Plus (Salt/Mix) THEOBID JR AB00052106 SAM002554935 Constant T Theoclear LA AC-20328 Slo-bid D0F8RA Theodur Dry Syrup Aescin-IIA Somophyllin T (8alpha, 9S)-10,11-Dihydro-6'-methoxycinchonan-9-amine trihydrochloride, min. 90% Theolair-SR Aquaphyllin SPECTRUM1500568 1,3-Dimethyl-2,6-dioxo-1,2,3,6-tetrahydropurine Theophyl-SR BCBcMAP01_000071 SR-01000075195-1 1024160-72-2 Theophylline 1.0 mg/ml in Methanol BRD-K97799481-001-02-0 KS-000010T0 Prestwick0_000873 Liquophylline Pseudotheophylline MLS002152943 Theotard NC00542 Unifyl DivK1c_000203 NCGC00018117-08 UPCMLD-DP123 EC 200-385-7 NCGC00018117-16 Xantivent Elixophyllin SR NCGC00022112-05 FT-0631259 NCGC00259924-01 HMS3259O06 NSC757346 InChI=1/C7H8N4O2/c1-10-5-4(8-3-9-5)6(12)11(2)7(10)13/h3H,1-2H3,(H,8,9 PDSP1_001018 Bronchodid Duracap Telb-DS 3,7-Dihydro-1,3-dimethyl-1H-purine-2,6-dione Theophylline, >=99.0% (HPLC) BSPBio_002363 Teolair 6461-EP2272841A1 Theophylline-[8-3H Theo Dur 6461-EP2301933A1 Quadrinal component of Mudrane GG elixir (Salt/Mix) Theo-Nite 75448-53-2 Quibron-T/SR component of Tedral (Salt/Mix) Theocin AB00052106-23 SC-95891 CPD000058537 Theoconfin Continuous Acet-theocin SMP1_000291 Theofol Afonilum Retard Somophyllin-t 1,3 Dimethylxanthine Theona P Asbron Spectrum4_000353 1,3-Dimethyl-3,7-dihydro-1H-purine-2,6-dione # BIDD:ER0557 ST024762 1H-Purine-2, 3,7-dihydro-1,3-dimethyl- Theophylline Anhydrous, USP PDSP2_001218 L000595 Prestwick2_000820 Maphylline Pulmo-Timelets MLS006011970 Tox21_110827_1 NCGC00018117-03 Uniphyl DSSTox_GSID_21336 NCGC00018117-11 WLN: T56 BM DN FNVNVJ F1 H1 Elixex NCGC00018117-19 ZINC18043251 Etheophyl NCGC00022112-09 GTPL413 NINDS_000203 HSDB 3399 Nuelin S.A. KBio2_004086 1H-Purine-2,6-dione, 3,7-dihydro-1,3-dimethyl-, mo Theophylline melting point standard, United States Pharmacopeia (USP) Reference Standard Bronkodyl Telbans DrySyrup 4eoh Theophylline, British Pharmacopoeia (BP) Reference Standard CAS-58-55-9 Tesona 6461-EP2281813A1 Chronophyllin Theo-24 6461-EP2305219A1 Quibron T-SR component of Primatene tablets (Salt/Mix) Theobid 83377-EP2371823A1 Respid component of Theo-Organidin (Salt/Mix) Theoclear 80 AB00052106_26 SDCCGMLS-0066620.P001 CTK3J1985 Theodrip Aerolate III Solosin Theolair AKOS005434016 SPBio_002640 1,3-dimethyl-1H-purine-2,6(3H,9H)-dione Theophyl Austyn Spophyllin retard 1,3-dimethyl-7H-purine-2,6-dione Theophylline (JP15) BPBio1_000791 Synophylate KBioGR_000785 Physpan Lanophyllin Prestwick3_000873 MFCD00079619 Theostat Purine-2,6(1H,3H)-dione, 1,3-dimethyl- Mudrane Uni-Dur Diffumal NCGC00018117-06 Uniphyllin continus Duraphyl NCGC00018117-14 Xanthine,3-dimethyl- Elixophyllin NCGC00022112-03 Euphylong NCGC00022112-12 HMS2092M05 NSC-757346 I14-16783 Optiphyllin Talotren 2a3a Theophylline [USP] BSPBio_000719 Teofilina [Polish] 6461-EP1441224A2 Theophylline, Pharmaceutical Secondary Standard; Certified Reference Material Cetraphylline Theal tablets 6461-EP2295434A2 component of Dicurin Procaine (Salt/Mix) Theo-dur 6461-EP2311827A1 Quibron-T component of Quibron-T/SR (Salt/Mix) Theobid Jr. AB00052106-20 SBI-0050003.P004 Constant-T Theoclear-200 AC1L1D1F Slo-phyllin DB-053224 Theodur G Afonilm Somophyllin-CRT Theolix Armophylline Spectrum2_000842 1,3-Dimethyl-2,6-dioxo-1,2,3,6-tetrahydropurine; 1,3-Dimethylxanthine; 3,7-Dihydro-1,3-dimethyl-1H-purine-2,6-dione Theophyline BDBM10847 SR-01000075195-3 Theophylline aminoacetate BRD-K97799481-001-12-9 PDSP1_001234 KS-0000477R Prestwick1_000820 Lopac0_000014 PubChem9695 MLS002153487 Theovent NCGC00018117-01 UNII-0I55128JYK Doraphyllin NCGC00018117-09 UPCMLD-DP123:001 Egifilin NCGC00018117-17 Z271004650 Elixophyllin(e) NCGC00022112-07 Glycine Theophyllinate NCI60_001736 HMS3369N14 Nuelin KBio1_000203 Theophylline Anhydrous,(S) Bronchoparat Telbans Theophylline, anhydrous C07130 Teonova 6461-EP2272844A1 Theoplus CHEMBL190 theo von ct 6461-EP2301936A1 Quibron T component of Primatene Theo-Organidin 8-(2-Furyl)theophylline Respbid component of Theo-organdin (Salt/Mix) Theoclair-SR AB00052106_24 SCHEMBL4915 CS-4158 Theocontin Aerobin SMR000058537 Theograd AI3-50216 SomophyllinT 1,3-dimethyl-1,3,7-trihydropurine-2,6-dione Theonite Asmalix Spectrum5_001232 1,3-dimethyl-3,9-dihydro-1H-purine-2,6-dione Theophylline (1,3-dimethylxanthine) BIDD:GT0151 STK397040 1H-purine-2,6-dione Pharmakon1600-01500568 LaBID Prestwick2_000873 MCULE-8236489917 Purine,6(1H,3H)-dione, 1,3-dimethyl- MolPort-001-002-058 Tox21_202375 NCGC00018117-04 Uniphyl (TN) DSSTox_RID_76090 NCGC00018117-12 X 115 Elixicon NCGC00018117-20 Euphyllin NCGC00022112-10 HMS1921E03 NSC 2066 HY-B0809 Nuelin SA KBio2_006654 1H-Purine-2,6-dione, 3,9-dihydro-1,3-dimethyl- theophylline solu-tion Bronkodyl SR Teocen 200 56645-32-0 Theophylline, certified reference material, United States Pharmacopeia (USP) Reference Standard CCG-20301 Theacitin 6461-EP2281815A1 component of Bronkotabs (Salt/Mix) Theo-24 (TN) 6461-EP2305640A2 Quibron T/SR component of Quibron (Salt/Mix) Theobid Duracap A3133D49-AAB6-49A1-B60B-B5198F327D3F RP24142 component of Theolair plus (Salt/Mix) Theoclear L.A.-130 AB1009249 Slo Phyllin D00371 Theodur Aerolate SR Somophyllin CRT Theolair (TN) AN-23602 SPBio_002866 1,3-dimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-dione Theophyl-225 BBL023514 SR-01000075195 1,3-Dimethylxanthine Theophylline (JP17) BPBio1_001041 Synophylate-L.A. Cenules |
Inchi Key | ZFXYFBGIUFBOJW-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C7H8N4O2/c1-10-5-4(8-3-9-5)6(12)11(2)7(10)13/h3H,1-2H3,(H,8,9) |
PubChem CID | 2153 |
ChEMBL | CHEMBL190 |
IUPHAR | 413 |
BindingDB | 82053, 10847 |
DrugBank | DB00277 |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
Ki | 4550.0 nM | PMID2067592 | BindingDB |
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