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GPCR

Name5-hydroxytryptamine receptor 7
SpeciesRattus norvegicus (Rat)
GeneHtr7
SynonymGPRFO
5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled
5-HTx
5-HT7 receptor
5-HT7
[ Show all ]
DiseaseN/A for non-human GPCRs
Length448
Amino acid sequenceMMDVNSSGRPDLYGHLRSLILPEVGRGLQDLSPDGGAHPVVSSWMPHLLSGFLEVTASPAPTWDAPPDNVSGCGEQINYGRVEKVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGWAQNVNDDKVCLISQDFGYTIYSTAVAFYIPMSVMLFMYYQIYKAARKSAAKHKFPGFPRVQPESVISLNGVVKLQKEVEECANLSRLLKHERKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCSCIPLWVERTCLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQYRNINRKLSAAGMHEALKLAERPERSEFVLQNSDHCGKKGHDT
UniProtP32305
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3223
IUPHAR12
DrugBankN/A

Ligand

NameBDBM50359426
Molecular formulaC22H27N3O2
IUPAC name1-hydroxy-2-[4-(2-naphthalen-1-ylethylamino)butyl]-6,7-dihydro-5H-pyrrolo[1,2-c]imidazol-3-one
Molecular weight365.477
Hydrogen bond acceptor3
Hydrogen bond donor2
XlogP3.3
SynonymsN/A
Inchi KeyCIKAFPKBAOFJTC-UHFFFAOYSA-N
Inchi IDInChI=1S/C22H27N3O2/c26-21-20-11-6-16-24(20)22(27)25(21)15-4-3-13-23-14-12-18-9-5-8-17-7-1-2-10-19(17)18/h1-2,5,7-10,23,26H,3-4,6,11-16H2
PubChem CID90752437
ChEMBLN/A
IUPHARN/A
BindingDB50359426
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Ki<1000.0 nMPMID22029386BindingDB

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