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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	5-hydroxytryptamine receptor 6
Species	Mus musculus (Mouse)
Gene	Htr6
Synonym	5-HT-6 5-HT6 5-HT6 receptor 5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled Serotonin receptor 6 ST-B17 [ Show all ]
Disease	N/A for non-human GPCRs
Length	440
Amino acid sequence	MVPEPGPVNSSTPAWGPGPPPAPGGSGWVAAALCVVIVLTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLCLISLDRYLLILSPLRYKLRMTAPRALALILGAWSLAALASFLPLLLGWHELGKARTSAPGQCRLLASLPYVLVASGVTFFLPSGAICFTYCRILLAARKQAVQVASLTTGTATAGQALETLQVPRTPRPGMESADSRRLTTKHSRKALKASLTLGILLSMFFVTWLPFFVASIAQAVCDCISPGLFDVLTWLGYCNSTMNPIIYPLFMRDFKRALGRFVPCVHCPPEHRASPASPSMWTSHSGARPGLSLQQVLPLPLPPNSDSDSASGGTSGLQLTAQLLLPGEATRDPPPPTRAPTVVNFFVTDSVEPEIRQHPLGSPMN
UniProt	Q9R1C8
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL1075268
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	SB-258510
Molecular formula	C21H24ClN3O3S2
IUPAC name	5-chloro-N-[4-methoxy-3-(4-methylpiperazin-1-yl)phenyl]-3-methyl-1-benzothiophene-2-sulfonamide
Molecular weight	466.011
Hydrogen bond acceptor	7
Hydrogen bond donor	1
XlogP	4.7
Synonyms	AC1OCFOR ZINLARKOVIPOJW-UHFFFAOYSA-N 5-Chloro-3-methyl-benzo[b]thiophene-2-sulfonic acid [4-methoxy-3-(4-methyl-piperazin-1-yl)-phenyl]-amide CHEMBL29846 5-chloro-N-[4-methoxy-3-(4-methylpiperazin-1-yl)phenyl]-3-methyl-1-benzothiophene-2-sulfonamide BDBM50130286 5-chloro-3-methyl-benzo[b]thiophene-2-sulphonic acid [4-methoxy-3-(4-methyl-piperazin-1-yl)phenyl]amide PDSP1_001372 SCHEMBL1136525 5-chloro-3-methyl-benzo[b]thiophene-2-sulphonic acid[4-methoxy-3-(4-methyl-piperazin-1-yl)phenyl]amide PDSP2_001356 [ Show all ]
Inchi Key	ZINLARKOVIPOJW-UHFFFAOYSA-N
Inchi ID	InChI=1S/C21H24ClN3O3S2/c1-14-17-12-15(22)4-7-20(17)29-21(14)30(26,27)23-16-5-6-19(28-3)18(13-16)25-10-8-24(2)9-11-25/h4-7,12-13,23H,8-11H2,1-3H3
PubChem CID	6918648
ChEMBL	CHEMBL29846
IUPHAR	N/A
BindingDB	50130286
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	1.0 nM	PMID14645659	BindingDB

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