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GPCR

Name	P2Y purinoceptor 2
Species	Homo sapiens (Human)
Gene	P2RY2
Synonym	Purinergic receptor purinergic receptor P2Y P2Y2 receptor P2Y2 P2Y purinoceptor 2 P2Y ATP receptor 2 P2U1 P2U receptor 1 P2U purinoceptor 1 ATP receptor [ Show all ]
Disease	Dry eye disease Constipation Cystic fibrosis Lung cancer
Length	377
Amino acid sequence	MAADLGPWNDTINGTWDGDELGYRCRFNEDFKYVLLPVSYGVVCVPGLCLNAVALYIFLCRLKTWNASTTYMFHLAVSDALYAASLPLLVYYYARGDHWPFSTVLCKLVRFLFYTNLYCSILFLTCISVHRCLGVLRPLRSLRWGRARYARRVAGAVWVLVLACQAPVLYFVTTSARGGRVTCHDTSAPELFSRFVAYSSVMLGLLFAVPFAVILVCYVLMARRLLKPAYGTSGGLPRAKRKSVRTIAVVLAVFALCFLPFHVTRTLYYSFRSLDLSCHTLNAINMAYKVTRPLASANSCLDPVLYFLAGQRLVRFARDAKPPTGPSPATPARRRLGLRRSDRTDMQRIEDVLGSSEDSRRTESTPAGSENTKDIRL
UniProt	P41231
Protein Data Bank	N/A
GPCR-HGmod model	P41231
3D structure model	This predicted structure model is from GPCR-EXP P41231.
BioLiP	N/A
Therapeutic Target Database	T93515
ChEMBL	CHEMBL4398
IUPHAR	324
DrugBank	BE0002401

Ligand

Name	Adenosine triphosphate
Molecular formula	C10H16N5O13P3
IUPAC name	[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] phosphono hydrogen phosphate
Molecular weight	507.181
Hydrogen bond acceptor	17
Hydrogen bond donor	7
XlogP	-5.7
Synonyms	Adenosine 5'-triphosphate Tox21_112044 Adenosine 5'-triphosphoric acid X5319 Adenylpyrophosphoric acid AN-41693 ATPase 1b38 bmse000854 1r0x CHEBI:15422 DB-022415 51569-41-6 Epitope ID:135612 9H-purin-6-amine, 9-[5-O-[hydroxy[[hydroxy(phosphonooxy)phosphinyl]oxy]phosphinyl] MolPort-002-533-479 Phosphobion Adenosine 5'-triphosphate (intravenous, arrhythmia), Duska Triphosadenine (DCF) adenosine-5'-triphosphate [(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl (hydroxy-phosphonooxyphosphoryl) hydrogen phosphate Ado-5'-P-P-P Atipi 065A467 BDBM50366480 1gz4 C00002 1vjc CS-7674 34369-07-8 DSSTox_CID_2559 84412-18-0 Glucobasin AC1L1LHX ST24045923 Adenosine 5'-triphosphate; Triphosphaden UNII-8L70Q75FXE Adenosintriphosphorsaeure AK-54737 ATP disodium hydrate 16488-07-6 Bio1_001384 1mau CAS-56-65-5 1y8p D08646 5'-Atp DTXSID6022559 9-beta-D-Arabinofuranosyladenine 5'-triphosphate HY-B2176 adenosine 5' triphosphate Adenosine 5'-triphosphate (intravenous, arrhythmia) Triadenyl ZINC4261765 Adephos Ara-ATP ((2R,3S,4R,5R)-5-(6-Amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl tetrahydrogen triphosphate Atriphos 1b39 bmse000993 1r10 2cbz 56-65-5 Fosfobion 9H-Purin-6-amine, 9-[5-O-[hydroxy[[hydroxy(phosphonooxy)phosphinyl]oxy]phosphinyl]-.beta.-D-ribofuranosyl]- Myotriphos RT-001349 Adenosine 5'-triphosphate (intravenous, bradycardia-induced syncopy (fainting)), Duska Triphosphaden adenosine-5'-triphosphoric acid [[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl]methoxy-hydroxy-phosphoryl] phosphono hydrogen phosphate Adynol ATP 10168-83-9 Bio1_000406 1kxp C10H16N5O13P3 1vjd CTK3J3236 3h-adenosine triphosphate DSSTox_GSID_22559 896506-78-8 GTPL1713 ACT02649 Striadyne Adenosine 5'-triphosphorate W-105506 Adenylpyrophosphorate AKOS022179934 ATPace bmse000006 1maw CC-23792 1yid D0O6QI EINECS 200-283-2 917074-14-7 LS-15176 Adenosine 5'-(tetrahydrogen triphosphate) Adenosine 5'-triphosphate (intravenous, arrhythmia), Cordex Triphosaden Adenosine, 5'-(tetrahydrogen triphosphate) ZKHQWZAMYRWXGA-KQYNXXCUSA-N Adetol AS-19204 ({[({[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy](hydroxy)phosphoryl}oxy)phosphonic acid BDBM2 1gz3 C-22981 1t44 CHEMBL14249 2fgh DB00171 71800-44-7 FT-0621909 A9788C43-4BC5-46E2-8560-41C5FA7D3AA3 NCGC00163309-01 SCHEMBL8979 Adenosine 5'-triphosphate (intravenous, paroxysmal supraventricular tachycardia (PSVT)), Duska Triphosphoric acid adenosine ester adenosine-triphosphate [[[(2R,3S,4R,5R)-5-(6-Aminopurin-9-yl)-3,4-dihydroxy-oxolan-2-yl]methoxy-hydroxy-phosphoryl]oxy-hydroxy-phosphoryl]oxyphosphonic acid AJ-70571 ATP (nucleotide) 1259312-93-0 Bio1_000895 1m83 Cardenosine 1xsc D02LMZ 5'-(tetrahydrogen triphosphate) Adenosine DSSTox_RID_76629 8L70Q75FXE H4atp Adenosine 5 inverted exclamation marka-triphosphate (ATP) disodium salt hydrate [ Show all ]
Inchi Key	ZKHQWZAMYRWXGA-KQYNXXCUSA-N
Inchi ID	InChI=1S/C10H16N5O13P3/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(26-10)1-25-30(21,22)28-31(23,24)27-29(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H,23,24)(H2,11,12,13)(H2,18,19,20)/t4-,6-,7-,10-/m1/s1
PubChem CID	5957
ChEMBL	CHEMBL14249
IUPHAR	1713
BindingDB	2, 50366480
DrugBank	DB00171
Structure SDF download
Lipinski's druglikeness	This ligand has more than 5 hydrogen bond donor. This ligand has more than 10 hydrogen bond acceptor. This ligand is heavier than 500 daltons.

Experimental Data

Parameter	Value	Reference	Database source
EC50	<300000.0 nM	PMID19419204	ChEMBL
EC50	30.1 nM	PMID19419204	ChEMBL
EC50	63.1 nM	PMID19419204	BindingDB,ChEMBL
EC50	79.4328 - 229.087 nM	PMID8564228, PMID11754592, PMID12213051	IUPHAR
EC50	85.0 nM	PMID11985476, PMID19419868, PMID17302398	BindingDB,ChEMBL
EC50	95.8 nM	PMID19419204	BindingDB,ChEMBL
EC50	111.0 nM	PMID19419204	ChEMBL
EC50	120.0 nM	PMID19419204	ChEMBL
EC50	183.0 nM	PMID19419204	ChEMBL
EC50	230.0 nM	PMID12213051	BindingDB,ChEMBL
EC50	237.0 nM	PMID19419204	ChEMBL
EC50	239.0 nM	PMID19419204	ChEMBL
EC50	299.0 nM	PMID19419204	ChEMBL
EC50	1000.0 nM	PMID19419204	ChEMBL
EC50	11700.0 nM	PMID19419204	ChEMBL
Efficacy	5.0 %	PMID19419204	ChEMBL
Efficacy	41.0 %	PMID19419204	ChEMBL
Efficacy	87.0 %	PMID19419204	ChEMBL
Efficacy	92.0 %	PMID19419204	ChEMBL
Efficacy	97.0 %	PMID19419204	ChEMBL
Efficacy	104.0 %	PMID19419204	ChEMBL
Efficacy	110.0 %	PMID19419204	ChEMBL
Efficacy	115.0 %	PMID19419204	ChEMBL
Efficacy	117.0 %	PMID19419204	ChEMBL
Efficacy	126.0 %	PMID19419204	ChEMBL
Efficacy	130.0 %	PMID19419204	ChEMBL
Ratio EC50	2.0 -	PMID19419204	ChEMBL
Ratio EC50	3.0 -	PMID19419204	ChEMBL
Ratio EC50	4.0 -	PMID19419204	ChEMBL
Ratio EC50	10.0 -	PMID19419204	ChEMBL