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Name | 5-hydroxytryptamine receptor 2A |
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Species | Homo sapiens (Human) |
Gene | HTR2A |
Synonym | 5-HT-2 serotonin receptor 2A serotonin 5HT-2 receptor 5-HT-2A 5-HT2A receptor [ Show all ] |
Disease | Depression Unspecified Diabetes Erythropoietic porphyria Fibromyalgia [ Show all ] |
Length | 471 |
Amino acid sequence | MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV |
UniProt | P28223 |
Protein Data Bank | 6a93, 6a94 |
GPCR-HGmod model | P28223 |
3D structure model | This structure is from PDB ID 6a93. |
BioLiP | BL0441025,BL0441028, BL0441031, BL0441030,BL0441033, BL0441029,BL0441032, BL0441026, BL0441024,BL0441027 |
Therapeutic Target Database | T32060 |
ChEMBL | CHEMBL224 |
IUPHAR | 6 |
DrugBank | BE0000451 |
Name | 64022-27-1 |
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Molecular formula | C8H11ClN4 |
IUPAC name | 2-chloro-6-piperazin-1-ylpyrazine |
Molecular weight | 198.654 |
Hydrogen bond acceptor | 4 |
Hydrogen bond donor | 1 |
XlogP | 0.5 |
Synonyms | 62C3N7238U BPBio1_000111 D02ESW LS-127601 NSC317326 [ Show all ] |
Inchi Key | CJAWPFJGFFNXQI-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C8H11ClN4/c9-7-5-11-6-8(12-7)13-3-1-10-2-4-13/h5-6,10H,1-4H2 |
PubChem CID | 107992 |
ChEMBL | CHEMBL269521 |
IUPHAR | 165 |
BindingDB | 50017452 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
EC50 | 420.0 nM | PMID23301527 | BindingDB,ChEMBL |
EC50 | 426.58 nM | PMID23301527 | ChEMBL |
EC50 | 1200.0 nM | PMID23301527 | BindingDB,ChEMBL |
EC50 | 1202.26 nM | PMID23301527 | ChEMBL |
Emax | 97.0 % | PMID23301527 | ChEMBL |
Emax | 101.0 % | PMID23301527 | ChEMBL |
Ki | 1000.0 nM | PMID15322733 | IUPHAR |
Ki | 1023.29 nM | PMID15322733 | BindingDB |
Ki | 1023.29 nM | PMID15322733 | PDSP |
Ki | 20893.0 nM | PMID23301527 | ChEMBL |
Ki | 21000.0 nM | PMID23301527 | BindingDB,ChEMBL |
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