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GPCR

Name5-hydroxytryptamine receptor 1B
SpeciesRattus norvegicus (Rat)
GeneHtr1b
Synonym5-HT1B
Serotonin receptor 1B
5-HT-1B
5-HT1B receptor
5-HT1DB
[ Show all ]
DiseaseN/A for non-human GPCRs
Length386
Amino acid sequenceMEEQGIQCAPPPPATSQTGVPLANLSHNCSADDYIYQDSIALPWKVLLVALLALITLATTLSNAFVIATVYRTRKLHTPANYLIASLAVTDLLVSILVMPISTMYTVTGRWTLGQVVCDFWLSSDITCCTASIMHLCVIALDRYWAITDAVDYSAKRTPKRAAIMIVLVWVFSISISLPPFFWRQAKAEEEVLDCFVNTDHVLYTVYSTVGAFYLPTLLLIALYGRIYVEARSRILKQTPNKTGKRLTRAQLITDSPGSTSSVTSINSRVPEVPSESGSPVYVNQVKVRVSDALLEKKKLMAARERKATKTLGIILGAFIVCWLPFFIISLVMPICKDACWFHMAIFDFFNWLGYLNSLINPIIYTMSNEDFKQAFHKLIRFKCTG
UniProtP28564
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3459
IUPHAR2
DrugBankN/A

Ligand

Name64022-27-1
Molecular formulaC8H11ClN4
IUPAC name2-chloro-6-piperazin-1-ylpyrazine
Molecular weight198.654
Hydrogen bond acceptor4
Hydrogen bond donor1
XlogP0.5
Synonyms2-Chloro-6-(1-piperazinyl)pyrazine
MK-212
MK 212
6-Chloro-2-(1-piperazinyl)pyrazine
2-chloro-6-(piperazin-1-yl)pyrazine
[ Show all ]
Inchi KeyCJAWPFJGFFNXQI-UHFFFAOYSA-N
Inchi IDInChI=1S/C8H11ClN4/c9-7-5-11-6-8(12-7)13-3-1-10-2-4-13/h5-6,10H,1-4H2
PubChem CID107992
ChEMBLCHEMBL269521
IUPHAR165
BindingDB50017452
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Ki178.0 nMPMID2565400BindingDB,ChEMBL
Ki3630.0 nMPMID4009617BindingDB,ChEMBL
Ki6000.0 nMPMID4009617BindingDB,ChEMBL

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