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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Free fatty acid receptor 1
Species	Mus musculus (Mouse)
Gene	Ffar1
Synonym	FFA1 receptor FFA1R G protein-coupled receptor 40 G-protein coupled receptor 40 GPR40
Disease	N/A for non-human GPCRs
Length	300
Amino acid sequence	MDLPPQLSFALYVSAFALGFPLNLLAIRGAVSHAKLRLTPSLVYTLHLGCSDLLLAITLPLKAVEALASGAWPLPLPFCPVFALAHFAPLYAGGGFLAALSAGRYLGAAFPFGYQAIRRPRYSWGVCVAIWALVLCHLGLALGLETSGSWLDNSTSSLGINIPVNGSPVCLEAWDPDSARPARLSFSILLFFLPLVITAFCYVGCLRALVRSGLSHKRKLRAAWVAGGALLTLLLCLGPYNASNVASFINPDLGGSWRKLGLITGAWSVVLNPLVTGYLGTGPGRGTICVTRTQRGTIQK
UniProt	Q76JU9
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL5411
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	865231-46-5
Molecular formula	C26H21F3O3
IUPAC name	(3S)-3-[4-[[3-[4-(trifluoromethyl)phenyl]phenyl]methoxy]phenyl]hex-4-ynoic acid
Molecular weight	438.446
Hydrogen bond acceptor	6
Hydrogen bond donor	1
XlogP	6.2
Synonyms	(S)-3-[4-[4'-(Trifluoromethyl)-3-biphenylylmethoxy]phenyl]-4-hexynoic acid AMG 837 BDBM50362690 FT-0772001 UNII-NE6U6R66U4 API0019508 CHEMBL1829173 KB-211342 (3S)-3-[4-({3-[4-(trifluoromethyl)phenyl]phenyl}methoxy)phenyl]hex-4-ynoic acid AJ-119043 B5834 DTXSID00676764 SB16974 3568AC AMG-837 C26H21F3O3 GTPL6485 ZINC72118116 AS-51920 CS-3278 NCGC00386948-01 (S)-3-(4-((4'-(Trifluoromethyl)-[1,1'-biphenyl]-3-yl)methoxy)phenyl)hex-4-ynoic acid AKOS016009081 BC600585 EX-A1792 SCHEMBL12194429 AMG837 HY-13967 (3S)-3-(4-{[4'-(Trifluoromethyl)[1,1'-biphenyl]-3-yl]methoxy}phenyl)hex-4-ynoic acid AC-30223 AX8228266 D0Q7BG NE6U6R66U4 [ Show all ]
Inchi Key	ZOPNBMMVVZRSGH-NRFANRHFSA-N
Inchi ID	InChI=1S/C26H21F3O3/c1-2-4-21(16-25(30)31)20-9-13-24(14-10-20)32-17-18-5-3-6-22(15-18)19-7-11-23(12-8-19)26(27,28)29/h3,5-15,21H,16-17H2,1H3,(H,30,31)/t21-/m0/s1
PubChem CID	46854655
ChEMBL	CHEMBL1829173
IUPHAR	6485
BindingDB	50362690
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
EC50	13.0 nM	PMID22217876	BindingDB,ChEMBL

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