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GLASS

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GPCR

Name	5-hydroxytryptamine receptor 2C
Species	Homo sapiens (Human)
Gene	HTR2C
Synonym	Serotonin receptor 2C serotonin 1c receptor 5-HT1C 5-HT2C 5-HT-2C 5-HT2C receptor 5-HTR2C 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled 5-hydroxytryptamine receptor 1C HTR1C 5-HT-1C [ Show all ]
Disease	Pain Sleep initiation and maintenance disorders; Primary insomnia; Schizophrenia Unspecified Depression Drug abuse Generalized anxiety disorder; Major depressive disorder Major depressive disorder Metabolic disorders Psychotic disorders Mood disorder Neurological disease Obesity Obesity; Diabetes Migraine headaches Anxiety disorder Alcohol use disorders Aggressive non-hodgkin's lymphoma [ Show all ]
Length	458
Amino acid sequence	MVNLRNAVHSFLVHLIGLLVWQCDISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSIVIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYVLRRQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNARRRKKKERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGRELNVNIYRHTNEPVIEKASDNEPGIEMQVENLELPVNPSSVVSERISSV
UniProt	P28335
Protein Data Bank	6bqg, 6bqh
GPCR-HGmod model	P28335
3D structure model	This structure is from PDB ID 6bqg.
BioLiP	BL0404805, BL0404806
Therapeutic Target Database	T83813
ChEMBL	CHEMBL225
IUPHAR	8
DrugBank	BE0004957, BE0004881, BE0000533

Ligand

Name	chlorpromazine
Molecular formula	C17H19ClN2S
IUPAC name	3-(2-chlorophenothiazin-10-yl)-N,N-dimethylpropan-1-amine
Molecular weight	318.863
Hydrogen bond acceptor	3
Hydrogen bond donor	0
XlogP	5.2
Synonyms	Chloropromazine 10H-Phenothiazine-10-propanamine, 2-chloro-N,N-dimethyl-, radical ion(1+) Chlorpromazine [USAN:INN:BAN] 2-Chloropromazine cMAP_000017 3-(2-chlorophenothiazin-10-yl)-N,N-dimethyl-propan-1-amine DB00477 Epitope ID:136898 AKOS001490972 Hibernal (Salt/Mix) AN-41563 I14-6226 Bio1_000457 KBio2_003190 BSPBio_002011 KBioSS_000622 Tranzine (Salt/Mix) NCGC00015273-15 ZPEIMTDSQAKGNT-UHFFFAOYSA-N NCGC00024409-08 NSC167745 Phenothiazine, 2-chloro-10-(3-(dimethylamino)propyl)- Prestwick3_000064 Psychozine L000182 SCHEMBL8321 Lopac-C-8138 Spectrum2_001156 MolPort-001-727-953 Thorazine NCGC00015273-07 (chloropromazine) [3-(2-Chloro-phenothiazin-10-yl)-propyl]-dimethyl-amine Chlorpromazin 2-Chloro-10-(3-(dimethylamino)propyl)phenothiazine Chlorpromazinum 2601-A Cromedazine 4560 R.P DSSTox_GSID_22808 AB00051943-16 Fenaktyl Aminazin HMS2089C12 BAS 00010434 JHICC02042 Biomol-NT_000020 KBio2_007448 CAS-50-53-3 KS-5101 Chlor-PZ NCGC00015273-10 Unitensen NCGC00015273-19 [3-(2-Chloro-phenothiazin-10-yl)-propyl]-dimethyl-amine Novo-Chlorpromazine Oprea1_110255 Plegomazin Promapar R1242 Largactil Liquid SKF-2601 M-1209 Spectrum5_000717 NCGC00015273-02 Thorazine Spansule 10-(3-Dimethylaminopropyl)-2-chlorophenothiazine Chlorpromazine cation radical 2-Chloro-10-[3-(dimethylamino)propyl]phenothiazine Clorpromazina [INN-Spanish] 3-(2-Chloro-10H-phenothiazin-10-yl)-N,N-dimethyl-1-propanamine # D01ZII 50-53-3 EINECS 200-045-8 AB0015094 GG 407 Amplicitil HMS501P06 BCP03610 KBio2_000622 BRD-K89997465-001-05-3 KBioGR_000806 CCRIS 3711 Chloro-3 (dimethylamino-3 propyl)-10 phenothiazine Tox21_110120 NCGC00015273-13 Z80 NCGC00024409-06 [3-(2-Chloro-phenothiazin-10-yl)-propyl]-dimethyl-amine(clorpromazine) NSC-167745 Phenathyl Prestwick1_000064 Propaphenin SBI-0050237.P004 Largactyl SPBio_002168 Megaphen SR-01000000012-6 NCGC00015273-05 Chlorpromados 1N,1N-dimethyl-3-(2-chloro-10H-10-phenothiazinyl)-1-propanamine Chlorpromazine [USP:INN:BAN] 2-Cloro-10 (3-dimetilaminopropil)fenotiazina Contomin 3-(2-chlorophenothiazin-10-yl)-N,N-dimethylpropan-1-amine DivK1c_000624 AB00051943 Esmind ALBB-022464 HL 5746 API0001970 IDI1_000624 Bio1_000946 KBio2_004880 C06906 KBioSS_002314 CHEMBL71 U42B7VYA4P NCGC00015273-16 [3-(2-chloro-10H-phenothiazin-10-yl)propyl]dimethylamine NINDS_000624 NSC17479 Phenothiazine, 2-chloro-10-[3-(dimethylamino)propyl]- Proma QSPL 401 Largactil SKF 2601-A Lopac0_000249 Spectrum3_000346 N-(3-Dimethylaminopropyl)-3-chlorophenothiazine Thorazine (TN) NCGC00015273-08 (chlorpromazine)[3-(2-Chloro-phenothiazin-10-yl)-propyl]-dimethyl-amine 2-Chloro-10-(3-dimethylaminopropyl)phenothiazine Chlorpromazinum [INN-Latin] 2601A CTK1C5154 4560 R.P. DSSTox_RID_76736 AB00051943_17 Fraction AB Aminazine HMS2091E06 BBL028251 KB-232587 BPBio1_000273 KBio3_001231 CAS-69-09-0 KSC-315-032- Chlordelazine NCGC00015273-11 Wintermin NCGC00024409-04 [3-(2-Chloro-phenothiazin-10-yl)-propyl]-dimethyl-amine (chlor-promazine) Novomazina Pharmakon1600-01500184 Prazilpromactil Promazil RP-4560 Largactil Oral Drops SMR001453710 M176 Spectrum_000142 NCGC00015273-03 Thorazine Suppositories Chloro-3 (dimethylamino-3 propyl)-10 phenothiazine [French] 10H-Phenothiazine-10-propanamine, 2-chloro-N,N-dimethyl- Chlorpromazine Tannate 2-chloro-N,N-dimethyl-10H-Phenothiazine-10-propanamine Clorpromazina [Italian] 3-(2-chloro-10H-phenothiazin-10-yl)-N,N-dimethylpropan-1-amine Elmarin AC1L1EBT GTPL83 Amplictil HSDB 3033 BDBM50001888 KBio2_002312 BSPBio_000247 KBioGR_002312 CHEBI:3647 Tox21_110120_1 NCGC00015273-14 ZINC44027 NCGC00024409-07 NSC-756689 Phenothiazine hydrochloride Prestwick2_000064 Prozil SC-50091 Lomazine (Salt/Mix) SPECTRUM1500184 MLS003166901 STK182870 NCGC00015273-06 Chlorpromanyl (discontinued) 2-chloro-10-(3-(dimethylamino)propyl)-phenothiazine Chlorpromazine;[3-(2-Chloro-phenothiazin-10-yl)-propyl]-dimethyl-amine 2-Cloro-10 (3-dimetilaminopropil)fenotiazina [Italian] CPZ 34468-21-8 DSSTox_CID_2808 AB00051943-15 Fenactil Aminasine HMS1920M03 AX8120990 J10069 Bio1_001435 KBio2_005758 C17H19ClN2S KS-00002WW5 Chlor-Promanyl UNII-U42B7VYA4P NCGC00015273-17 [3-(2-chloro-10H-phenothiazin-10-yl)propyl]dimethylamine hydrochloride Norcozine (Salt/Mix) NSC756689 Plegomasine Promactil QTL1_000021 Largactil (TN) SKF 2601A LS-105361 Spectrum4_000283 NCGC00015273-01 Thorazine hydrochloride NCGC00015273-09 Chlorpromazine (USP/INN) 2-chloro-10-[3-(dimethylamino)propyl]- Clorpromazina 3-(2-Chloro-10H-phenothiazin-10-yl)-N,N-dimethyl-1-propanamine D00270 4560 Rp hydrochloride DTXSID0022808 AB00051943_18 FT-0653683 Ampliactil HMS3430C19 BC 135 KBio1_000624 BPBio1_001181 KBio3_002792 CCG-40059 KUC112482N Chlorderazin NCGC00015273-12 WLN: T C666 BN ISJ B3N1&1 EG NCGC00024409-05 [3-(2-Chloro-phenothiazin-10-yl)-propyl]-dimethyl-amine( Chlorpromazine) NSC 167745 Phenactyl Prestwick0_000064 Propaphen Sanopron Largactilothiazine SPBio_001111 MCULE-5976054678 SR-01000000012-5 NCGC00015273-04 Torazina [ Show all ]
Inchi Key	ZPEIMTDSQAKGNT-UHFFFAOYSA-N
Inchi ID	InChI=1S/C17H19ClN2S/c1-19(2)10-5-11-20-14-6-3-4-7-16(14)21-17-9-8-13(18)12-15(17)20/h3-4,6-9,12H,5,10-11H2,1-2H3
PubChem CID	2726
ChEMBL	CHEMBL71
IUPHAR	83
BindingDB	50001888
DrugBank	DB00477
Structure SDF download
Lipinski's druglikeness	This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
	N/A	N/A	DrugBank
IC50	5.235 nM	DrugMatrix in vitro pharmacology data	ChEMBL
Ki	1.4 nM	PMID2904784	BindingDB
Ki	2.742 nM	DrugMatrix in vitro pharmacology data	ChEMBL
Ki	6.1 nM	PMID10991983	PDSP
Ki	6.30957 - 25.1189 nM	PMID12629531, PMID10991983	IUPHAR
Ki	25.0 nM	PMID12629531	PDSP,BindingDB
Ki	27.0 nM	PMID21907583	BindingDB,ChEMBL
Ki	30.0 nM	PMID24365159	ChEMBL
Ki	30.2 nM	PMID24365159	ChEMBL
Ki	39.81 nM	PMID17880057	ChEMBL

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