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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	5-hydroxytryptamine receptor 6
Species	Homo sapiens (Human)
Gene	HTR6
Synonym	5-HT6 receptor 5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled 5-HT-6 serotonin receptor 6 ST-B17 5-HT6 [ Show all ]
Disease	Schizophrenia Obesity Neurological disease Neurodegenerative disease Emesis Cognitive disorders Unspecified Anxiety disorder Alzheimer disease; Dementia Alzheimer disease; Anxiety disorder Alzheimer disease [ Show all ]
Length	440
Amino acid sequence	MVPEPGPTANSTPAWGAGPPSAPGGSGWVAAALCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPLLLGWHELGHARPPVPGQCRLLASLPFVLVASGLTFFLPSGAICFTYCRILLAARKQAVQVASLTTGMASQASETLQVPRTPRPGVESADSRRLATKHSRKALKASLTLGILLGMFFVTWLPFFVANIVQAVCDCISPGLFDVLTWLGYCNSTMNPIIYPLFMRDFKRALGRFLPCPRCPRERQASLASPSLRTSHSGPRPGLSLQQVLPLPLPPDSDSDSDAGSGGSSGLRLTAQLLLPGEATQDPPLPTRAAAAVNFFNIDPAEPELRPHPLGIPTN
UniProt	P50406
Protein Data Bank	N/A
GPCR-HGmod model	P50406
3D structure model	This predicted structure model is from GPCR-EXP P50406.
BioLiP	N/A
Therapeutic Target Database	T16691
ChEMBL	CHEMBL3371
IUPHAR	11
DrugBank	BE0000945

Ligand

Name	chlorpromazine
Molecular formula	C17H19ClN2S
IUPAC name	3-(2-chlorophenothiazin-10-yl)-N,N-dimethylpropan-1-amine
Molecular weight	318.863
Hydrogen bond acceptor	3
Hydrogen bond donor	0
XlogP	5.2
Synonyms	Pharmakon1600-01500184 Prazilpromactil Promazil RP-4560 Largactil Oral Drops SMR001453710 M176 Spectrum_000142 NCGC00015273-03 Thorazine Suppositories NCGC00015273-11 Wintermin NCGC00024409-04 [3-(2-Chloro-phenothiazin-10-yl)-propyl]-dimethyl-amine (chlor-promazine) Novomazina BC 135 KBio1_000624 BPBio1_001181 KBio3_002792 CCG-40059 KUC112482N Chlorderazin Chlorpromazine (USP/INN) 2-chloro-10-[3-(dimethylamino)propyl]- Clorpromazina 3-(2-Chloro-10H-phenothiazin-10-yl)-N,N-dimethyl-1-propanamine D00270 4560 Rp hydrochloride DTXSID0022808 AB00051943_18 FT-0653683 Ampliactil HMS3430C19 Phenothiazine hydrochloride Prestwick2_000064 Prozil SC-50091 Lomazine (Salt/Mix) SPECTRUM1500184 MLS003166901 STK182870 NCGC00015273-06 Tox21_110120_1 NCGC00015273-14 ZINC44027 NCGC00024409-07 NSC-756689 I14-6226 Bio1_000457 KBio2_003190 BSPBio_002011 KBioSS_000622 Chloropromazine 10H-Phenothiazine-10-propanamine, 2-chloro-N,N-dimethyl-, radical ion(1+) Chlorpromazine [USAN:INN:BAN] 2-Chloropromazine cMAP_000017 3-(2-chlorophenothiazin-10-yl)-N,N-dimethyl-propan-1-amine DB00477 Epitope ID:136898 AKOS001490972 Hibernal (Salt/Mix) AN-41563 NSC756689 Plegomasine Promactil QTL1_000021 Largactil (TN) SKF 2601A LS-105361 Spectrum4_000283 NCGC00015273-01 Thorazine hydrochloride NCGC00015273-09 UNII-U42B7VYA4P NCGC00015273-17 [3-(2-chloro-10H-phenothiazin-10-yl)propyl]dimethylamine hydrochloride Norcozine (Salt/Mix) BAS 00010434 JHICC02042 Biomol-NT_000020 KBio2_007448 CAS-50-53-3 KS-5101 Chlor-PZ (chloropromazine) [3-(2-Chloro-phenothiazin-10-yl)-propyl]-dimethyl-amine Chlorpromazin 2-Chloro-10-(3-(dimethylamino)propyl)phenothiazine Chlorpromazinum 2601-A Cromedazine 4560 R.P DSSTox_GSID_22808 AB00051943-16 Fenaktyl Aminazin HMS2089C12 Phenactyl Prestwick0_000064 Propaphen Sanopron Largactilothiazine SPBio_001111 MCULE-5976054678 SR-01000000012-5 NCGC00015273-04 Torazina NCGC00015273-12 WLN: T C666 BN ISJ B3N1&1 EG NCGC00024409-05 [3-(2-Chloro-phenothiazin-10-yl)-propyl]-dimethyl-amine( Chlorpromazine) NSC 167745 HMS501P06 BCP03610 KBio2_000622 BRD-K89997465-001-05-3 KBioGR_000806 CCRIS 3711 Chloro-3 (dimethylamino-3 propyl)-10 phenothiazine 10-(3-Dimethylaminopropyl)-2-chlorophenothiazine Chlorpromazine cation radical 2-Chloro-10-[3-(dimethylamino)propyl]phenothiazine Clorpromazina [INN-Spanish] 3-(2-Chloro-10H-phenothiazin-10-yl)-N,N-dimethyl-1-propanamine # D01ZII 50-53-3 EINECS 200-045-8 AB0015094 GG 407 Amplicitil Phenothiazine, 2-chloro-10-(3-(dimethylamino)propyl)- Prestwick3_000064 Psychozine L000182 SCHEMBL8321 Lopac-C-8138 Spectrum2_001156 MolPort-001-727-953 Thorazine NCGC00015273-07 Tranzine (Salt/Mix) NCGC00015273-15 ZPEIMTDSQAKGNT-UHFFFAOYSA-N NCGC00024409-08 NSC167745 IDI1_000624 Bio1_000946 KBio2_004880 C06906 KBioSS_002314 CHEMBL71 Chlorpromados 1N,1N-dimethyl-3-(2-chloro-10H-10-phenothiazinyl)-1-propanamine Chlorpromazine [USP:INN:BAN] 2-Cloro-10 (3-dimetilaminopropil)fenotiazina Contomin 3-(2-chlorophenothiazin-10-yl)-N,N-dimethylpropan-1-amine DivK1c_000624 AB00051943 Esmind ALBB-022464 HL 5746 API0001970 Oprea1_110255 Plegomazin Promapar R1242 Largactil Liquid SKF-2601 M-1209 Spectrum5_000717 NCGC00015273-02 Thorazine Spansule NCGC00015273-10 Unitensen NCGC00015273-19 [3-(2-Chloro-phenothiazin-10-yl)-propyl]-dimethyl-amine Novo-Chlorpromazine BBL028251 KB-232587 BPBio1_000273 KBio3_001231 CAS-69-09-0 KSC-315-032- Chlordelazine (chlorpromazine)[3-(2-Chloro-phenothiazin-10-yl)-propyl]-dimethyl-amine 2-Chloro-10-(3-dimethylaminopropyl)phenothiazine Chlorpromazinum [INN-Latin] 2601A CTK1C5154 4560 R.P. DSSTox_RID_76736 AB00051943_17 Fraction AB Aminazine HMS2091E06 Phenathyl Prestwick1_000064 Propaphenin SBI-0050237.P004 Largactyl SPBio_002168 Megaphen SR-01000000012-6 NCGC00015273-05 Tox21_110120 NCGC00015273-13 Z80 NCGC00024409-06 [3-(2-Chloro-phenothiazin-10-yl)-propyl]-dimethyl-amine(clorpromazine) NSC-167745 HSDB 3033 BDBM50001888 KBio2_002312 BSPBio_000247 KBioGR_002312 CHEBI:3647 Chloro-3 (dimethylamino-3 propyl)-10 phenothiazine [French] 10H-Phenothiazine-10-propanamine, 2-chloro-N,N-dimethyl- Chlorpromazine Tannate 2-chloro-N,N-dimethyl-10H-Phenothiazine-10-propanamine Clorpromazina [Italian] 3-(2-chloro-10H-phenothiazin-10-yl)-N,N-dimethylpropan-1-amine Elmarin AC1L1EBT GTPL83 Amplictil Phenothiazine, 2-chloro-10-[3-(dimethylamino)propyl]- Proma QSPL 401 Largactil SKF 2601-A Lopac0_000249 Spectrum3_000346 N-(3-Dimethylaminopropyl)-3-chlorophenothiazine Thorazine (TN) NCGC00015273-08 U42B7VYA4P NCGC00015273-16 [3-(2-chloro-10H-phenothiazin-10-yl)propyl]dimethylamine NINDS_000624 NSC17479 AX8120990 J10069 Bio1_001435 KBio2_005758 C17H19ClN2S KS-00002WW5 Chlor-Promanyl Chlorpromanyl (discontinued) 2-chloro-10-(3-(dimethylamino)propyl)-phenothiazine Chlorpromazine;[3-(2-Chloro-phenothiazin-10-yl)-propyl]-dimethyl-amine 2-Cloro-10 (3-dimetilaminopropil)fenotiazina [Italian] CPZ 34468-21-8 DSSTox_CID_2808 AB00051943-15 Fenactil Aminasine HMS1920M03 [ Show all ]
Inchi Key	ZPEIMTDSQAKGNT-UHFFFAOYSA-N
Inchi ID	InChI=1S/C17H19ClN2S/c1-19(2)10-5-11-20-14-6-3-4-7-16(14)21-17-9-8-13(18)12-15(17)20/h3-4,6-9,12H,5,10-11H2,1-2H3
PubChem CID	2726
ChEMBL	CHEMBL71
IUPHAR	83
BindingDB	50001888
DrugBank	DB00477
Structure SDF download
Lipinski's druglikeness	This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
	N/A	N/A	DrugBank
IC50	57.0 nM	DrugMatrix in vitro pharmacology data	ChEMBL
Ki	4.0 nM	PMID12825922	BindingDB,ChEMBL
Ki	12.0 nM	http://pdsp.med.unc.edu/pdsp.php	PDSP
Ki	15.8489 - 19.9526 nM	PMID8522988, PMID15821958	IUPHAR
Ki	19.0 nM	PMID8522988	PDSP,BindingDB
Ki	20.1 nM	PMID12629531	PDSP,BindingDB
Ki	26.0 nM	DrugMatrix in vitro pharmacology data	ChEMBL
Ki	>50.0 nM	PMID15771424	ChEMBL
Ki	50.12 nM	PMID17880057	ChEMBL
Ki	60.0 nM	PMID24365159	ChEMBL
Ki	60.26 nM	PMID24365159	ChEMBL

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