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GPCR

Name5-hydroxytryptamine receptor 4
SpeciesHomo sapiens (Human)
GeneHTR4
Synonym5-HT-4
5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled
5-HT4 receptor
5-HT4
serotonin receptor 4
DiseaseN/A
Length388
Amino acid sequenceMDKLDANVSSEEGFGSVEKVVLLTFLSTVILMAILGNLLVMVAVCWDRQLRKIKTNYFIVSLAFADLLVSVLVMPFGAIELVQDIWIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMTPLRIALMLGGCWVIPTFISFLPIMQGWNNIGIIDLIEKRKFNQNSNSTYCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAHQIQMLQRAGASSESRPQSADQHSTHRMRTETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFIDYTVPGQVWTAFLWLGYINSGLNPFLYAFLNKSFRRAFLIILCCDDERYRRPSILGQTVPCSTTTINGSTHVLRDAVECGGQWESQCHPPATSPLVAAQPSDT
UniProtQ13639
Protein Data BankN/A
GPCR-HGmod modelQ13639
3D structure modelThis predicted structure model is from GPCR-EXP Q13639.
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL1875
IUPHAR9
DrugBankBE0000084

Ligand

NamePrucalopride
Molecular formulaC18H26ClN3O3
IUPAC name4-amino-5-chloro-N-[1-(3-methoxypropyl)piperidin-4-yl]-2,3-dihydro-1-benzofuran-7-carboxamide
Molecular weight367.874
Hydrogen bond acceptor5
Hydrogen bond donor2
XlogP2.0
SynonymsFT-0674128
Motegrity
PubChem22481
SC-23104
ZINC1891034
[ Show all ]
Inchi KeyZPMNHBXQOOVQJL-UHFFFAOYSA-N
Inchi IDInChI=1S/C18H26ClN3O3/c1-24-9-2-6-22-7-3-12(4-8-22)21-18(23)14-11-15(19)16(20)13-5-10-25-17(13)14/h11-12H,2-10,20H2,1H3,(H,21,23)
PubChem CID3052762
ChEMBLCHEMBL117287
IUPHAR243
BindingDB50122872
DrugBankDB06480

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
N/A N/ADrugBank
EC505.2 nMPMID26363507ChEMBL
Emax80.0 %PMID26363507ChEMBL
Ki<1000.0 nMPMID12540230BindingDB,ChEMBL
Ki2.5 nMPMID11438309BindingDB
Ki2.51189 - 100.0 nMPMID10646498, PMID11438309IUPHAR
Ki2.512 nMPMID19261477ChEMBL
Ki7.5 nMPMID12540230BindingDB,ChEMBL
Ki8.0 nMPMID11438309BindingDB
Ki63.09 nMPMID10646498BindingDB
Ki100.0 nMPMID10646498BindingDB
Ki110.0 nMPMID12540230BindingDB,ChEMBL

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