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GPCR

Name	Trace amine-associated receptor 1
Species	Homo sapiens (Human)
Gene	TAAR1
Synonym	trace amine receptor 1 TAR1 TaR-1 TA1 receptor TRAR1
Disease	N/A
Length	339
Amino acid sequence	MMPFCHNIINISCVKNNWSNDVRASLYSLMVLIILTTLVGNLIVIVSISHFKQLHTPTNWLIHSMATVDFLLGCLVMPYSMVRSAEHCWYFGEVFCKIHTSTDIMLSSASIFHLSFISIDRYYAVCDPLRYKAKMNILVICVMIFISWSVPAVFAFGMIFLELNFKGAEEIYYKHVHCRGGCSVFFSKISGVLTFMTSFYIPGSIMLCVYYRIYLIAKEQARLISDANQKLQIGLEMKNGISQSKERKAVKTLGIVMGVFLICWCPFFICTVMDPFLHYIIPPTLNDVLIWFGYLNSTFNPMVYAFFYPWFRKALKMMLFGKIFQKDSSRCKLFLELSS
UniProt	Q96RJ0
Protein Data Bank	N/A
GPCR-HGmod model	Q96RJ0
3D structure model	This predicted structure model is from GPCR-EXP Q96RJ0.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL5857
IUPHAR	364
DrugBank	BE0001044

Ligand

Name	2-(4-BROMOPHENYL)-N-METHYLETHANAMINE
Molecular formula	C9H12BrN
IUPAC name	2-(4-bromophenyl)-N-methylethanamine
Molecular weight	214.106
Hydrogen bond acceptor	1
Hydrogen bond donor	1
XlogP	2.4
Synonyms	4-BROMO-N-METHYL-BENZENEETHANAMINE ANW-36224 DTXSID00593169 N-[2-(4-Bromophenyl)ethyl]-N-methylamine ZINC34977644 AB27732 BENZENEETHANAMINE, 4-BROMO-N-METHYL- KB-14754 ST24021756 [2-(4-bromophenyl)ethyl]methylamine 2-(4-bromophenyl)-N-methylethan-1-amine AJ-90561 CJLDHHONSQXJTC-UHFFFAOYSA-N MolPort-013-283-637 V7496 B-4584 EN300-71266 SBB052416 [2-(4-BROMO-PHENYL)-ETHYL]-METHYL-AMINE AC1Q419B KS-00003TJO TC-124969 AKOS008124804 CTK5D6495 N-Methyl-2-(4-bromophenyl)ethylamine Z1266823359 725683-06-7 BDBM50262996 I05-657 SCHEMBL681646 [2-(4-bromophenyl)ethyl](methyl)amine 2-(4-Bromophenyl)-N-methyl ethanamine ACMC-209onm CHEMBL508125 MCULE-3456096699 TS-03057 [ Show all ]
Inchi Key	CJLDHHONSQXJTC-UHFFFAOYSA-N
Inchi ID	InChI=1S/C9H12BrN/c1-11-7-6-8-2-4-9(10)5-3-8/h2-5,11H,6-7H2,1H3
PubChem CID	18367556
ChEMBL	CHEMBL508125
IUPHAR	N/A
BindingDB	50262996
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	6540.0 nM	PMID18602830	BindingDB,ChEMBL
Emax	60.0 %	PMID18602830	ChEMBL

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