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GPCR

NameLutropin-choriogonadotropic hormone receptor
SpeciesRattus norvegicus (Rat)
GeneLhcgr
SynonymLuteinizing hormone receptor
LSH-R
LHR
LH/CG-R
LH-R
[ Show all ]
DiseaseN/A for non-human GPCRs
Length700
Amino acid sequenceMGRRVPALRQLLVLAVLLLKPSQLQSRELSGSRCPEPCDCAPDGALRCPGPRAGLARLSLTYLPVKVIPSQAFRGLNEVVKIEISQSDSLERIEANAFDNLLNLSELLIQNTKNLLYIEPGAFTNLPRLKYLSICNTGIRTLPDVTKISSSEFNFILEICDNLHITTIPGNAFQGMNNESVTLKLYGNGFEEVQSHAFNGTTLISLELKENIYLEKMHSGAFQGATGPSILDISSTKLQALPSHGLESIQTLIALSSYSLKTLPSKEKFTSLLVATLTYPSHCCAFRNLPKKEQNFSFSIFENFSKQCESTVRKADNETLYSAIFEENELSGWDYDYGFCSPKTLQCAPEPDAFNPCEDIMGYAFLRVLIWLINILAIFGNLTVLFVLLTSRYKLTVPRFLMCNLSFADFCMGLYLLLIASVDSQTKGQYYNHAIDWQTGSGCGAAGFFTVFASELSVYTLTVITLERWHTITYAVQLDQKLRLRHAIPIMLGGWLFSTLIATMPLVGISNYMKVSICLPMDVESTLSQVYILSILILNVVAFVVICACYIRIYFAVQNPELTAPNKDTKIAKKMAILIFTDFTCMAPISFFAISAAFKVPLITVTNSKILLVLFYPVNSCANPFLYAIFTKAFQRDFLLLLSRFGCCKRRAELYRRKEFSAYTSNCKNGFPGASKPSQATLKLSTVHCQQPIPPRALTH
UniProtP16235
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL2456
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL3272559
Molecular formulaC49H78N14O13
IUPAC name(2S)-N-[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2R)-1-[[(2S)-1-[[(2S)-1-[(2S)-2-[(2-amino-2-oxoethyl)carbamoyl]pyrrolidin-1-yl]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-1-oxopropan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]-5-oxopyrrolidine-2-carboxamide
Molecular weight1071.25
Hydrogen bond acceptor14
Hydrogen bond donor14
XlogP-1.6
SynonymsN/A
Inchi KeyZRQQPDDLLLARQY-WPOSIKJCSA-N
Inchi IDInChI=1S/C49H78N14O13/c1-24(2)20-32(43(71)57-31(10-8-18-53-49(51)52)48(76)63-19-9-11-35(63)45(73)54-22-36(50)66)58-40(68)27(7)55-42(70)33(21-28-12-14-29(65)15-13-28)59-44(72)34(23-64)60-46(74)38(25(3)4)62-47(75)39(26(5)6)61-41(69)30-16-17-37(67)56-30/h12-15,24-27,30-35,38-39,64-65H,8-11,16-23H2,1-7H3,(H2,50,66)(H,54,73)(H,55,70)(H,56,67)(H,57,71)(H,58,68)(H,59,72)(H,60,74)(H,61,69)(H,62,75)(H4,51,52,53)/t27-,30+,31+,32+,33+,34+,35+,38+,39+/m1/s1
PubChem CID90677608
ChEMBLCHEMBL3272559
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has more than 5 hydrogen bond donor.
This ligand has more than 10 hydrogen bond acceptor.
This ligand is heavier than 500 daltons.

Experimental Data

ParameterValueReferenceDatabase source
Activity17.0 ng/mlPMID765459ChEMBL
Activity35.0 ng/mlPMID765459ChEMBL
Activity313.0 ng/mlPMID765459ChEMBL
Activity770.0 ng/mlPMID765459ChEMBL
Activity850.0 ng/mlPMID765459ChEMBL
Activity4813.0 ng/mlPMID765459ChEMBL
MED100.0 ug ml-1PMID765459ChEMBL

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