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GLASS

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GPCR

Name	Galanin receptor type 3
Species	Homo sapiens (Human)
Gene	GALR3
Synonym	GAL3-R Galnr3 GALR-3 GALR3 GAL3 receptor
Disease	Cognitive disorders
Length	368
Amino acid sequence	MADAQNISLDSPGSVGAVAVPVVFALIFLLGTVGNGLVLAVLLQPGPSAWQEPGSTTDLFILNLAVADLCFILCCVPFQATIYTLDAWLFGALVCKAVHLLIYLTMYASSFTLAAVSVDRYLAVRHPLRSRALRTPRNARAAVGLVWLLAALFSAPYLSYYGTVRYGALELCVPAWEDARRRALDVATFAAGYLLPVAVVSLAYGRTLRFLWAAVGPAGAAAAEARRRATGRAGRAMLAVAALYALCWGPHHALILCFWYGRFAFSPATYACRLASHCLAYANSCLNPLVYALASRHFRARFRRLWPCGRRRRHRARRALRRVRPASSGPPGCPGDARPSGRLLAGGGQGPEPREGPVHGGEAARGPE
UniProt	O60755
Protein Data Bank	N/A
GPCR-HGmod model	O60755
3D structure model	This predicted structure model is from GPCR-EXP O60755.
BioLiP	N/A
Therapeutic Target Database	T98494
ChEMBL	CHEMBL2731
IUPHAR	245
DrugBank	N/A

Ligand

Name	MLS000712366
Molecular formula	C16H14BrN3
IUPAC name	2-benzyl-5-(4-bromophenyl)pyrazol-3-amine
Molecular weight	328.213
Hydrogen bond acceptor	2
Hydrogen bond donor	1
XlogP	3.8
Synonyms	5-(4-bromophenyl)-2-(phenylmethyl)-3-pyrazolamine CHEMBL1547757 SMR000282133 1-benzyl-3-(4-bromophenyl)-1H-pyrazol-5-amine AC1LEX4F MCULE-9127979473 SR-01000518074-3 3-(4-bromophenyl)-1-benzylpyrazole-5-ylamine BDBM46413 Oprea1_166206 ZINC66583 5-(4-bromophenyl)-2-(phenylmethyl)pyrazol-3-amine cid_693933 SR-01000518074 2-Benzyl-5-(4-bromo-phenyl)-2H-pyrazol-3-ylamine AKOS000641741 ST4034853 Oprea1_611849 [2-benzyl-5-(4-bromophenyl)pyrazol-3-yl]amine A1676/0071484 HMS2690N20 SR-01000518074-1 2-benzyl-5-(4-bromophenyl)pyrazol-3-amine BAS 00831409 MolPort-001-947-713 STK757005 [ Show all ]
Inchi Key	CKBWLLOYCRFXFT-UHFFFAOYSA-N
Inchi ID	InChI=1S/C16H14BrN3/c17-14-8-6-13(7-9-14)15-10-16(18)20(19-15)11-12-4-2-1-3-5-12/h1-10H,11,18H2
PubChem CID	693933
ChEMBL	CHEMBL1547757
IUPHAR	N/A
BindingDB	46413
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	3553.0 nM	, PubChem BioAssay data set	BindingDB,ChEMBL

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