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Name | D(2) dopamine receptor |
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Species | Homo sapiens (Human) |
Gene | DRD2 |
Synonym | dopamine receptor 2 Dopamine D2 receptor D2R D2A and D2B D2(415) and D2(444) [ Show all ] |
Disease | Substance dependence Major depressive disorder Maintain blood pressure in hypotensive states Insomnia Inflammatory disease [ Show all ] |
Length | 443 |
Amino acid sequence | MDPLNLSWYDDDLERQNWSRPFNGSDGKADRPHYNYYATLLTLLIAVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMISIVWVLSFTISCPLLFGLNNADQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRRRRKRVNTKRSSRAFRAHLRAPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRVEAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSTPDSPAKPEKNGHAKDHPKIAKIFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFLKILHC |
UniProt | P14416 |
Protein Data Bank | 6cm4, 6c38 |
GPCR-HGmod model | P14416 |
3D structure model | This structure is from PDB ID 6cm4. |
BioLiP | BL0408379, BL0403379 |
Therapeutic Target Database | T67162 |
ChEMBL | CHEMBL217 |
IUPHAR | 215 |
DrugBank | BE0000756 |
Name | BUTACLAMOL |
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Molecular formula | C25H31NO |
IUPAC name | 6-tert-butyl-3-azapentacyclo[11.8.1.03,8.09,22.016,21]docosa-9,11,13(22),16,18,20-hexaen-6-ol |
Molecular weight | 361.529 |
Hydrogen bond acceptor | 2 |
Hydrogen bond donor | 1 |
XlogP | 5.0 |
Synonyms | L000016 BDBM86721 CHEMBL13035 AC1L1AZZ NSC_37459 [ Show all ] |
Inchi Key | ZZJYIKPMDIWRSN-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C25H31NO/c1-24(2,3)25(27)13-14-26-16-21-19-9-5-4-7-17(19)11-12-18-8-6-10-20(23(18)21)22(26)15-25/h4-10,21-22,27H,11-16H2,1-3H3 |
PubChem CID | 1224 |
ChEMBL | N/A |
IUPHAR | N/A |
BindingDB | 86721 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
Ki | <10000.0 nM | PMID8097160, PMID2532362 | PDSP |
Ki | 0.05 nM | PMID9577836 | PDSP |
Ki | 0.09 nM | PMID8935801 | PDSP |
Ki | 0.3 nM | PMID16135699 | PDSP,BindingDB |
Ki | 0.4 nM | PMID16135699 | PDSP,BindingDB |
Ki | 0.44 nM | PMID8301582 | PDSP |
Ki | 0.68 nM | PMID1828505 | PDSP |
Ki | 0.74 nM | PMID1828505 | PDSP |
Ki | 0.8 nM | PMID1840645 | PDSP |
Ki | 0.83 nM | PMID1828505 | PDSP |
Ki | 0.86 nM | PMID2904784, PMID6149136 | PDSP |
Ki | 0.94 nM | PMID2532362 | PDSP |
Ki | 1.0 nM | PMID9686407 | PDSP |
Ki | 1.1 nM | PMID8097160 | PDSP |
Ki | 1.2 nM | PMID1828505 | PDSP |
Ki | 1.8 nM | PMID1828505 | PDSP |
Ki | 1000.0 nM | PMID8301582 | PDSP |
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