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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	Hydroxycarboxylic acid receptor 2
Species	Homo sapiens (Human)
Gene	HCAR2
Synonym	G-protein coupled receptor HM74A G-protein coupled receptor 109A PUMAG Nicotinic acid receptor HCA2 receptor Nic1 Niacin receptor 1 Niacr1 G protein-coupled receptor 109A [ Show all ]
Disease	Hyperlipidaemia Acute ischemic stroke Arteriosclerosis Atherosclerosis Cardiovascular disorder Major depressive disorder Type 2 diabetes [ Show all ]
Length	363
Amino acid sequence	MNRHHLQDHFLEIDKKNCCVFRDDFIVKVLPPVLGLEFIFGLLGNGLALWIFCFHLKSWKSSRIFLFNLAVADFLLIICLPFLMDNYVRRWDWKFGDIPCRLMLFMLAMNRQGSIIFLTVVAVDRYFRVVHPHHALNKISNRTAAIISCLLWGITIGLTVHLLKKKMPIQNGGANLCSSFSICHTFQWHEAMFLLEFFLPLGIILFCSARIIWSLRQRQMDRHAKIKRAITFIMVVAIVFVICFLPSVVVRIRIFWLLHTSGTQNCEVYRSVDLAFFITLSFTYMNSMLDPVVYYFSSPSFPNFFSTLINRCLQRKMTGEPDNNRSTSVELTGDPNKTRGAPEALMANSGEPWSPSYLGPTSP
UniProt	Q8TDS4
Protein Data Bank	N/A
GPCR-HGmod model	Q8TDS4
3D structure model	This predicted structure model is from GPCR-EXP Q8TDS4.
BioLiP	N/A
Therapeutic Target Database	T00864
ChEMBL	CHEMBL3785
IUPHAR	312
DrugBank	BE0000635

Ligand

Name	4-Methoxycinnamic acid
Molecular formula	C10H10O3
IUPAC name	(E)-3-(4-methoxyphenyl)prop-2-enoic acid
Molecular weight	178.187
Hydrogen bond acceptor	3
Hydrogen bond donor	1
XlogP	1.8
Synonyms	830-09-1 P-METHOXYCINNAMIC ACID 3-(4-methoxyphenyl)acrylic acid 943-89-5 trans-4-Methoxycinnamic acid 4-Methoxycinnamate para-methoxycinnamic acid O-Methyl-p-coumaric acid Cinnamic acid, p-methoxy- (E)-3-(4-Methoxyphenyl)acrylic acid (E)-4-METHOXYCINNAMIC ACID 3-(4-Methoxyphenyl)-2-propenoic acid Cinnamic acid, 4-methoxy- 2-Propenoic acid, 3-(4-methoxyphenyl)- 2-Propenoic acid, 3-(4-methoxyphenyl)-, (2E)- (E)-3-(4-methoxyphenyl)-2-propenoic acid (2E)-3-(4-methoxyphenyl)prop-2-enoic acid METHOXYCINNAMIC ACID, PARA p-methoxycinnamate (E)-3-(4-methoxyphenyl)prop-2-enoic acid UNII-6G4ML8401A PMCA NSC 5303 P-Methoxy ciannamic acid EINECS 212-594-0 3-(4-methoxyphenyl)prop-2-enoic acid trans-3-(4-Methoxyphenyl)acrylic acid CHEMBL95770 AI3-23399 4-Methoxy-(2E)-cinnamic acid (2E)-3-(4-METHOXYPHENYL)ACRYLIC ACID AFDXODALSZRGIH-QPJJXVBHSA-N trans-2-Propenoic acid, 3-(4-methoxyphenyl)- 6G4ML8401A NSC-5303 MFCD00004398 NSC-623437 NCGC00159448-02 (E)-3-(4-Methoxy-phenyl)-acrylic acid 4-Methoxy cinnamic acid p-Methoxycinnamic acid, 99%, predominantly trans (E)-p-Methoxycinnamic acid Bernel hydro 3-(4-Methoxy-phenyl)-acrylic acid EINECS 213-405-4 para-methoxycinnamate 4-Methoxy cinnamate P-Methoxy ciannamate O-Methyl-p-coumarate PubChem8248 p-MCA p-methoxy-cinnamic acid trans-4-Methoxycinnamate AC1LF8QH AC1Q5RAR O-Methyl-p-cumaric Acid bmse010212 4-Methoxybenzeneacrylic acid DSSTox_CID_26059 DSSTox_RID_81310 2-Propenoic acid, 3-(4-methoxyphenyl)-, (E)- AKOS BBB/225 DSSTox_GSID_46059 SCHEMBL58699 (E)-p-Methoxy-cinnamic acid MLS002473129 trans-4-methoxy-cinnamic acid RARECHEM BK HC T257 ARONIS000351 METHOXYCINNAMIC ACID,4- 3-(4-Methoxy-phenyl)-acrylate DTXSID1046059 AFDXODALSZRGIH-QPJJXVBHSA- CHEBI:48541 TIMTEC-BB SBB005717 ZINC77999 NSC5303 AKOS B000181 MolPort-000-655-960 ART-CHEM-BB B000181 HMS1783A08 HMS2267B19 (E)-3-(4-Methoxyphenyl)acrylate 3-(4-methoxyphenyl)-2-Propenoate ALBB-011726 BCP21420 HY-N1387 7340-42-3 (hydrochloride salt) AKOS BBS-00000769 Tox21_111674 AKOS A1230-2778 BBL012085 BDBM50146453 LABOTEST-BB LT00108121 LABOTEST-BB LT03333631 NSC623437 SBB005717 STK005095 AKOS000118882 AS01561 EBD2197791 LS11390 MCULE-6993960877 MP-2212 PS-5777 RP17443 RTR-025896 RTR-029508 (E)-3-(4-methoxyphenyl)-acrylic acid OTAVA-BB 0123400502 NCGC00159448-03 NCGC00159448-04 30-09-1 AC-10371 AJ-10423 AK-98686 AN-20523 CAS-943-89-5 KB-72675 SC-50019 SC-77648 SMR000112200 ST098720 4-Methoxycinnamic acid, >=98.0% (GC) p-Methoxycinnamic acid, predominantly trans 4-Methoxycinnamic acid, predominantly trans AB1003581 LS-123672 ST2410363 TR-029508 TR-049560 CS-0016807 M0576 AZ0001-0155 (2E)-3-(4-Methoxyphenyl)-2-propenoic acid # 4-Methoxycinnamic acid, predominantly trans, 99% 830M091 A837404 AE-641/00135031 I04-9543 W-100196 W-104154 F1638-0067 0C546A89-9721-4B4E-89EE-7EC28A9A3391 InChI=1/C10H10O3/c1-13-9-5-2-8(3-6-9)4-7-10(11)12/h2-7H,1H3,(H,11,12)/b7-4+ [ Show all ]
Inchi Key	AFDXODALSZRGIH-QPJJXVBHSA-N
Inchi ID	InChI=1S/C10H10O3/c1-13-9-5-2-8(3-6-9)4-7-10(11)12/h2-7H,1H3,(H,11,12)/b7-4+
PubChem CID	699414
ChEMBL	CHEMBL95770
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Activity	0.0 %	PMID21167710	ChEMBL

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