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GPCR

NameProbable G-protein coupled receptor 88
SpeciesHomo sapiens (Human)
GeneGPR88
SynonymGPR88
STRG
striatum-specific G-protein coupled receptor
DiseaseN/A
Length384
Amino acid sequenceMTNSSSTSTSSTTGGSLLLLCEEEESWAGRRIPVSLLYSGLAIGGTLANGMVIYLVSSFRKLQTTSNAFIVNGCAADLSVCALWMPQEAVLGLLPTGSAEPPADWDGAGGSYRLLRGGLLGLGLTVSLLSHCLVALNRYLLITRAPATYQALYQRRHTAGMLALSWALALGLVLLLPPWAPRPGAAPPRVHYPALLAAAALLAQTALLLHCYLGIVRRVRVSVKRVSVLNFHLLHQLPGCAAAAAAFPGAQHAPGPGGAAHPAQAQPLPPALHPRRAQRRLSGLSVLLLCCVFLLATQPLVWVSLASGFSLPVPWGVQAASWLLCCALSALNPLLYTWRNEEFRRSVRSVLPGVGDAAAAAVAATAVPAVSQAQLGTRAAGQHW
UniProtQ9GZN0
Protein Data BankN/A
GPCR-HGmod modelQ9GZN0
3D structure modelThis predicted structure model is from GPCR-EXP Q9GZN0.
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3399910
IUPHAR123
DrugBankN/A

Ligand

NameCHEMBL3403789
Molecular formulaC22H30N2O3
IUPAC name(2S)-N-[(1R)-2-hydroxy-1-[2-methyl-6-[(2S)-2-methylbutoxy]pyridin-3-yl]ethyl]-2-phenylpropanamide
Molecular weight370.493
Hydrogen bond acceptor4
Hydrogen bond donor2
XlogP3.9
SynonymsBDBM50064760
Inchi KeyAKHOLLDFJCNZSY-FTRWYGJKSA-N
Inchi IDInChI=1S/C22H30N2O3/c1-5-15(2)14-27-21-12-11-19(17(4)23-21)20(13-25)24-22(26)16(3)18-9-7-6-8-10-18/h6-12,15-16,20,25H,5,13-14H2,1-4H3,(H,24,26)/t15-,16-,20-/m0/s1
PubChem CID118730012
ChEMBLCHEMBL3403789
IUPHARN/A
BindingDB50064760
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
EC50260.0 nMPMID25690789BindingDB,ChEMBL

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