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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	Neuropeptide FF receptor 1
Species	Homo sapiens (Human)
Gene	NPFFR1
Synonym	GnIH-R G protein-coupled receptor 147 OT7T022 NPFF1R1 NPFF1 receptor NPFF1 G-protein coupled receptor 147 GPR147 GnIH-R/RFRP-3 RFamide-related peptide receptor OT7T022 [ Show all ]
Disease	N/A
Length	430
Amino acid sequence	MEGEPSQPPNSSWPLSQNGTNTEATPATNLTFSSYYQHTSPVAAMFIVAYALIFLLCMVGNTLVCFIVLKNRHMHTVTNMFILNLAVSDLLVGIFCMPTTLVDNLITGWPFDNATCKMSGLVQGMSVSASVFTLVAIAVERFRCIVHPFREKLTLRKALVTIAVIWALALLIMCPSAVTLTVTREEHHFMVDARNRSYPLYSCWEAWPEKGMRRVYTTVLFSHIYLAPLALIVVMYARIARKLCQAPGPAPGGEEAADPRASRRRARVVHMLVMVALFFTLSWLPLWALLLLIDYGQLSAPQLHLVTVYAFPFAHWLAFFNSSANPIIYGYFNENFRRGFQAAFRARLCPRPSGSHKEAYSERPGGLLHRRVFVVVRPSDSGLPSESGPSSGAPRPGRLPLRNGRVAHHGLPREGPGCSHLPLTIPAWDI
UniProt	Q9GZQ6
Protein Data Bank	N/A
GPCR-HGmod model	Q9GZQ6
3D structure model	This predicted structure model is from GPCR-EXP Q9GZQ6.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL5951
IUPHAR	300
DrugBank	N/A

Ligand

Name	CHEMBL3360831
Molecular formula	C19H33N7O
IUPAC name	(2S)-2-amino-N-[(4-anilino-1-methylpiperidin-4-yl)methyl]-5-(diaminomethylideneamino)pentanamide
Molecular weight	375.521
Hydrogen bond acceptor	5
Hydrogen bond donor	5
XlogP	-0.1
Synonyms	BDBM50029139
Inchi Key	ALXATRYNMFDYIV-INIZCTEOSA-N
Inchi ID	InChI=1S/C19H33N7O/c1-26-12-9-19(10-13-26,25-15-6-3-2-4-7-15)14-24-17(27)16(20)8-5-11-23-18(21)22/h2-4,6-7,16,25H,5,8-14,20H2,1H3,(H,24,27)(H4,21,22,23)/t16-/m0/s1
PubChem CID	118724538
ChEMBL	CHEMBL3360831
IUPHAR	N/A
BindingDB	50029139
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	<5000.0 nM	PMID25268943	BindingDB,ChEMBL

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