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GPCR

NameProbable G-protein coupled receptor 88
SpeciesHomo sapiens (Human)
GeneGPR88
SynonymGPR88
STRG
striatum-specific G-protein coupled receptor
DiseaseN/A
Length384
Amino acid sequenceMTNSSSTSTSSTTGGSLLLLCEEEESWAGRRIPVSLLYSGLAIGGTLANGMVIYLVSSFRKLQTTSNAFIVNGCAADLSVCALWMPQEAVLGLLPTGSAEPPADWDGAGGSYRLLRGGLLGLGLTVSLLSHCLVALNRYLLITRAPATYQALYQRRHTAGMLALSWALALGLVLLLPPWAPRPGAAPPRVHYPALLAAAALLAQTALLLHCYLGIVRRVRVSVKRVSVLNFHLLHQLPGCAAAAAAFPGAQHAPGPGGAAHPAQAQPLPPALHPRRAQRRLSGLSVLLLCCVFLLATQPLVWVSLASGFSLPVPWGVQAASWLLCCALSALNPLLYTWRNEEFRRSVRSVLPGVGDAAAAAVAATAVPAVSQAQLGTRAAGQHW
UniProtQ9GZN0
Protein Data BankN/A
GPCR-HGmod modelQ9GZN0
3D structure modelThis predicted structure model is from GPCR-EXP Q9GZN0.
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3399910
IUPHAR123
DrugBankN/A

Ligand

NameCHEMBL3400281
Molecular formulaC31H39N3O
IUPAC name(1R,2R)-N-[(2S,3S)-2-amino-3-methylpentyl]-N-[4-[4-[(dimethylamino)methyl]phenyl]phenyl]-2-phenylcyclopropane-1-carboxamide
Molecular weight469.673
Hydrogen bond acceptor3
Hydrogen bond donor1
XlogP5.4
SynonymsBDBM50065921
Inchi KeyAXZWPZCQFBXRDT-NQIRKQEASA-N
Inchi IDInChI=1S/C31H39N3O/c1-5-22(2)30(32)21-34(31(35)29-19-28(29)26-9-7-6-8-10-26)27-17-15-25(16-18-27)24-13-11-23(12-14-24)20-33(3)4/h6-18,22,28-30H,5,19-21,32H2,1-4H3/t22-,28-,29+,30+/m0/s1
PubChem CID118727690
ChEMBLCHEMBL3400281
IUPHARN/A
BindingDB50065921
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has a partition coefficient log P greater than 5.

Experimental Data

ParameterValueReferenceDatabase source
EC50460.0 nMPMID25754495BindingDB,ChEMBL

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