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GPCR

NameProbable G-protein coupled receptor 88
SpeciesHomo sapiens (Human)
GeneGPR88
SynonymGPR88
STRG
striatum-specific G-protein coupled receptor
DiseaseN/A
Length384
Amino acid sequenceMTNSSSTSTSSTTGGSLLLLCEEEESWAGRRIPVSLLYSGLAIGGTLANGMVIYLVSSFRKLQTTSNAFIVNGCAADLSVCALWMPQEAVLGLLPTGSAEPPADWDGAGGSYRLLRGGLLGLGLTVSLLSHCLVALNRYLLITRAPATYQALYQRRHTAGMLALSWALALGLVLLLPPWAPRPGAAPPRVHYPALLAAAALLAQTALLLHCYLGIVRRVRVSVKRVSVLNFHLLHQLPGCAAAAAAFPGAQHAPGPGGAAHPAQAQPLPPALHPRRAQRRLSGLSVLLLCCVFLLATQPLVWVSLASGFSLPVPWGVQAASWLLCCALSALNPLLYTWRNEEFRRSVRSVLPGVGDAAAAAVAATAVPAVSQAQLGTRAAGQHW
UniProtQ9GZN0
Protein Data BankN/A
GPCR-HGmod modelQ9GZN0
3D structure modelThis predicted structure model is from GPCR-EXP Q9GZN0.
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3399910
IUPHAR123
DrugBankN/A

Ligand

NameCHEMBL3400232
Molecular formulaC26H30N2OS
IUPAC name(1R,2R)-N-[(2S,3S)-2-amino-3-methylpentyl]-N-(4-phenylphenyl)-2-thiophen-3-ylcyclopropane-1-carboxamide
Molecular weight418.599
Hydrogen bond acceptor3
Hydrogen bond donor1
XlogP5.2
SynonymsBDBM50065717
Inchi KeyBDUNJXZLFYAAGX-URPHZZJISA-N
Inchi IDInChI=1S/C26H30N2OS/c1-3-18(2)25(27)16-28(26(29)24-15-23(24)21-13-14-30-17-21)22-11-9-20(10-12-22)19-7-5-4-6-8-19/h4-14,17-18,23-25H,3,15-16,27H2,1-2H3/t18-,23-,24+,25+/m0/s1
PubChem CID118727641
ChEMBLCHEMBL3400232
IUPHARN/A
BindingDB50065717
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has a partition coefficient log P greater than 5.

Experimental Data

ParameterValueReferenceDatabase source
EC50450.0 nMPMID25754495BindingDB,ChEMBL

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