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GPCR

NameHydroxycarboxylic acid receptor 2
SpeciesHomo sapiens (Human)
GeneHCAR2
SynonymG-protein coupled receptor HM74A
G-protein coupled receptor 109A
PUMAG
Nicotinic acid receptor
HCA2 receptor
[ Show all ]
DiseaseHyperlipidaemia
Acute ischemic stroke
Arteriosclerosis
Atherosclerosis
Cardiovascular disorder
[ Show all ]
Length363
Amino acid sequenceMNRHHLQDHFLEIDKKNCCVFRDDFIVKVLPPVLGLEFIFGLLGNGLALWIFCFHLKSWKSSRIFLFNLAVADFLLIICLPFLMDNYVRRWDWKFGDIPCRLMLFMLAMNRQGSIIFLTVVAVDRYFRVVHPHHALNKISNRTAAIISCLLWGITIGLTVHLLKKKMPIQNGGANLCSSFSICHTFQWHEAMFLLEFFLPLGIILFCSARIIWSLRQRQMDRHAKIKRAITFIMVVAIVFVICFLPSVVVRIRIFWLLHTSGTQNCEVYRSVDLAFFITLSFTYMNSMLDPVVYYFSSPSFPNFFSTLINRCLQRKMTGEPDNNRSTSVELTGDPNKTRGAPEALMANSGEPWSPSYLGPTSP
UniProtQ8TDS4
Protein Data BankN/A
GPCR-HGmod modelQ8TDS4
3D structure modelThis predicted structure model is from GPCR-EXP Q8TDS4.
BioLiPN/A
Therapeutic Target DatabaseT00864
ChEMBLCHEMBL3785
IUPHAR312
DrugBankBE0000635

Ligand

NameCHEMBL492027
Molecular formulaC27H30N4O2
IUPAC nameN-(1-methoxy-3-phenylpropan-2-yl)-7-methyl-3-(4-propan-2-ylphenyl)pyrazolo[1,5-a]pyrimidine-6-carboxamide
Molecular weight442.563
Hydrogen bond acceptor4
Hydrogen bond donor1
XlogP4.6
SynonymsBDBM50264294
rac-3-(4-isopropylphenyl)-N-(1-methoxy-3-phenylpropan-2-yl)-7-methylpyrazolo[1,5-a]pyrimidine-6-carboxamide
Inchi KeyCKMVPHVWDXGMBF-UHFFFAOYSA-N
Inchi IDInChI=1S/C27H30N4O2/c1-18(2)21-10-12-22(13-11-21)25-16-29-31-19(3)24(15-28-26(25)31)27(32)30-23(17-33-4)14-20-8-6-5-7-9-20/h5-13,15-16,18,23H,14,17H2,1-4H3,(H,30,32)
PubChem CID44579780
ChEMBLCHEMBL492027
IUPHARN/A
BindingDB50264294
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Activity31.0 %PMID18752940ChEMBL
EC501400.0 nMPMID18752940BindingDB,ChEMBL

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