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GPCR

NameMas-related G-protein coupled receptor member X1
SpeciesMus musculus (Mouse)
GeneMrgprx1
SynonymMas-related G-protein coupled receptor member C11
Sensory neuron-specific G-protein coupled receptor 1
DiseaseN/A for non-human GPCRs
Length322
Amino acid sequenceMDPTISSHDTESTPLNETGHPNCTPILTLSFLVLITTLVGLAGNTIVLWLLGFRMRRKAISVYILNLALADSFFLCCHFIDSLLRIIDFYGLYAHKLSKDILGNAAIIPYISGLSILSAISTERCLCVLWPIWYHCHRPRNMSAIICALIWVLSFLMGILDWFSGFLGETHHHLWKNVDFIITAFLIFLFMLLSGSSLALLLRILCGPRRKPLSRLYVTIALTVMVYLICGLPLGLYLFLLYWFGVHLHYPFCHIYQVTAVLSCVNSSANPIIYFLVGSFRQHRKHRSLKRVLKRALEDTPEEDEYTDSHLHKTTEISESRY
UniProtQ8CIP3
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3341576
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL3343991
Molecular formulaC16H24N6O2
IUPAC name(2S,4S)-N-[(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]-4-[(diaminomethylideneamino)methyl]pyrrolidine-2-carboxamide
Molecular weight332.408
Hydrogen bond acceptor4
Hydrogen bond donor5
XlogP-1.0
SynonymsN/A
Inchi KeyBFLKQEFSKSGPPF-AVGNSLFASA-N
Inchi IDInChI=1S/C16H24N6O2/c17-14(23)12(6-10-4-2-1-3-5-10)22-15(24)13-7-11(8-20-13)9-21-16(18)19/h1-5,11-13,20H,6-9H2,(H2,17,23)(H,22,24)(H4,18,19,21)/t11-,12-,13-/m0/s1
PubChem CID118717465
ChEMBLCHEMBL3343991
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
EC50501.19 nMPMID25288495ChEMBL

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