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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Glucose-dependent insulinotropic receptor
Species	Homo sapiens (Human)
Gene	GPR119
Synonym	GPCR2 GPR119 G-protein coupled receptor 2 G-protein coupled receptor 119 G protein-coupled receptor 119 glucose-dependent insulinotropic receptor [ Show all ]
Disease	Type 2 diabetes Diabetes Peripheral arterial disease; Type 2 diabetes Non-insulin dependent diabetes Gastric cancer; Type 2 diabetes
Length	335
Amino acid sequence	MESSFSFGVILAVLASLIIATNTLVAVAVLLLIHKNDGVSLCFTLNLAVADTLIGVAISGLLTDQLSSPSRPTQKTLCSLRMAFVTSSAAASVLTVMLITFDRYLAIKQPFRYLKIMSGFVAGACIAGLWLVSYLIGFLPLGIPMFQQTAYKGQCSFFAVFHPHFVLTLSCVGFFPAMLLFVFFYCDMLKIASMHSQQIRKMEHAGAMAGGYRSPRTPSDFKALRTVSVLIGSFALSWTPFLITGIVQVACQECHLYLVLERYLWLLGVGNSLLNPLIYAYWQKEVRLQLYHMALGVKKVLTSFLLFLSARNCGPERPRESSCHIVTISSSEFDG
UniProt	Q8TDV5
Protein Data Bank	N/A
GPCR-HGmod model	Q8TDV5
3D structure model	This predicted structure model is from GPCR-EXP Q8TDV5.
BioLiP	N/A
Therapeutic Target Database	T93788
ChEMBL	CHEMBL5652
IUPHAR	126
DrugBank	N/A

Ligand

Name	CHEMBL3354781
Molecular formula	C27H24F3N3O2
IUPAC name	ethyl (9R)-9-benzyl-3-[4-(trifluoromethyl)phenyl]-7,8-dihydro-6H-pyrazolo[1,5-a]quinazoline-9-carboxylate
Molecular weight	479.503
Hydrogen bond acceptor	7
Hydrogen bond donor	0
XlogP	5.8
Synonyms	BDBM50036644
Inchi Key	BHFTZDZOYKINDA-AREMUKBSSA-N
Inchi ID	InChI=1S/C27H24F3N3O2/c1-2-35-25(34)26(15-18-7-4-3-5-8-18)14-6-9-20-16-31-24-22(17-32-33(24)23(20)26)19-10-12-21(13-11-19)27(28,29)30/h3-5,7-8,10-13,16-17H,2,6,9,14-15H2,1H3/t26-/m1/s1
PubChem CID	118720409
ChEMBL	CHEMBL3354781
IUPHAR	N/A
BindingDB	50036644
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
EC50	8.0 nM	PMID25455488	ChEMBL
EC50	8.0 nM	PMID25455488	BindingDB
Efficacy	75.0 %	PMID25455488	ChEMBL

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