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GPCR

NameProbable G-protein coupled receptor 88
SpeciesHomo sapiens (Human)
GeneGPR88
SynonymGPR88
STRG
striatum-specific G-protein coupled receptor
DiseaseN/A
Length384
Amino acid sequenceMTNSSSTSTSSTTGGSLLLLCEEEESWAGRRIPVSLLYSGLAIGGTLANGMVIYLVSSFRKLQTTSNAFIVNGCAADLSVCALWMPQEAVLGLLPTGSAEPPADWDGAGGSYRLLRGGLLGLGLTVSLLSHCLVALNRYLLITRAPATYQALYQRRHTAGMLALSWALALGLVLLLPPWAPRPGAAPPRVHYPALLAAAALLAQTALLLHCYLGIVRRVRVSVKRVSVLNFHLLHQLPGCAAAAAAFPGAQHAPGPGGAAHPAQAQPLPPALHPRRAQRRLSGLSVLLLCCVFLLATQPLVWVSLASGFSLPVPWGVQAASWLLCCALSALNPLLYTWRNEEFRRSVRSVLPGVGDAAAAAVAATAVPAVSQAQLGTRAAGQHW
UniProtQ9GZN0
Protein Data BankN/A
GPCR-HGmod modelQ9GZN0
3D structure modelThis predicted structure model is from GPCR-EXP Q9GZN0.
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3399910
IUPHAR123
DrugBankN/A

Ligand

NameCHEMBL3400282
Molecular formulaC30H37N3O
IUPAC name(1R,2R)-N-[(2S,3S)-2-amino-3-methylpentyl]-N-[4-[4-(methylaminomethyl)phenyl]phenyl]-2-phenylcyclopropane-1-carboxamide
Molecular weight455.646
Hydrogen bond acceptor3
Hydrogen bond donor2
XlogP4.9
SynonymsBDBM50065920
Inchi KeyBLWYNZKFLRWKQF-AGMJPXHESA-N
Inchi IDInChI=1S/C30H37N3O/c1-4-21(2)29(31)20-33(30(34)28-18-27(28)25-8-6-5-7-9-25)26-16-14-24(15-17-26)23-12-10-22(11-13-23)19-32-3/h5-17,21,27-29,32H,4,18-20,31H2,1-3H3/t21-,27-,28+,29+/m0/s1
PubChem CID118727691
ChEMBLCHEMBL3400282
IUPHARN/A
BindingDB50065920
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
EC506400.0 nMPMID25754495BindingDB,ChEMBL

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