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GPCR

NameAlpha-1B adrenergic receptor
SpeciesRattus norvegicus (Rat)
GeneAdra1b
Synonymalpha1B-adrenoceptor
alpha1B-adrenergic receptor
alpha 1B-adrenoreceptor
alpha 1B-adrenoceptor
Alpha-1B adrenoceptor
[ Show all ]
DiseaseN/A for non-human GPCRs
Length515
Amino acid sequenceMNPDLDTGHNTSAPAHWGELKDDNFTGPNQTSSNSTLPQLDVTRAISVGLVLGAFILFAIVGNILVILSVACNRHLRTPTNYFIVNLAIADLLLSFTVLPFSATLEVLGYWVLGRIFCDIWAAVDVLCCTASILSLCAISIDRYIGVRYSLQYPTLVTRRKAILALLSVWVLSTVISIGPLLGWKEPAPNDDKECGVTEEPFYALFSSLGSFYIPLAVILVMYCRVYIVAKRTTKNLEAGVMKEMSNSKELTLRIHSKNFHEDTLSSTKAKGHNPRSSIAVKLFKFSREKKAAKTLGIVVGMFILCWLPFFIALPLGSLFSTLKPPDAVFKVVFWLGYFNSCLNPIIYPCSSKEFKRAFMRILGCQCRGGRRRRRRRRLGACAYTYRPWTRGGSLERSQSRKDSLDDSGSCMSGTQRTLPSASPSPGYLGRGTQPPVELCAFPEWKPGALLSLPEPPGRRGRLDSGPLFTFKLLGDPESPGTEGDTSNGGCDTTTDLANGQPGFKSNMPLAPGHF
UniProtP15823
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL315
IUPHAR23
DrugBankN/A

Ligand

NameCHEMBL3342855
Molecular formulaC19H28N2O5S
IUPAC name3-[[4-(2-methoxyphenyl)piperazin-1-yl]methyl]-1,4-dioxa-8lambda6-thiaspiro[4.5]decane 8,8-dioxide
Molecular weight396.502
Hydrogen bond acceptor7
Hydrogen bond donor0
XlogP1.2
SynonymsBDBM50099439
Inchi KeyBQWXWYVQIVCGBP-UHFFFAOYSA-N
Inchi IDInChI=1S/C19H28N2O5S/c1-24-18-5-3-2-4-17(18)21-10-8-20(9-11-21)14-16-15-25-19(26-16)6-12-27(22,23)13-7-19/h2-5,16H,6-15H2,1H3
PubChem CID118716702
ChEMBLCHEMBL3342855
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
pKb7.66 -PMID25261823ChEMBL

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