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GPCR

NameProbable G-protein coupled receptor 88
SpeciesHomo sapiens (Human)
GeneGPR88
SynonymGPR88
STRG
striatum-specific G-protein coupled receptor
DiseaseN/A
Length384
Amino acid sequenceMTNSSSTSTSSTTGGSLLLLCEEEESWAGRRIPVSLLYSGLAIGGTLANGMVIYLVSSFRKLQTTSNAFIVNGCAADLSVCALWMPQEAVLGLLPTGSAEPPADWDGAGGSYRLLRGGLLGLGLTVSLLSHCLVALNRYLLITRAPATYQALYQRRHTAGMLALSWALALGLVLLLPPWAPRPGAAPPRVHYPALLAAAALLAQTALLLHCYLGIVRRVRVSVKRVSVLNFHLLHQLPGCAAAAAAFPGAQHAPGPGGAAHPAQAQPLPPALHPRRAQRRLSGLSVLLLCCVFLLATQPLVWVSLASGFSLPVPWGVQAASWLLCCALSALNPLLYTWRNEEFRRSVRSVLPGVGDAAAAAVAATAVPAVSQAQLGTRAAGQHW
UniProtQ9GZN0
Protein Data BankN/A
GPCR-HGmod modelQ9GZN0
3D structure modelThis predicted structure model is from GPCR-EXP Q9GZN0.
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3399910
IUPHAR123
DrugBankN/A

Ligand

NameCHEMBL3400270
Molecular formulaC29H31F3N2O2
IUPAC name(1R,2R)-N-[(2S,3S)-2-amino-3-methylpentyl]-2-phenyl-N-[4-[4-(trifluoromethoxy)phenyl]phenyl]cyclopropane-1-carboxamide
Molecular weight496.574
Hydrogen bond acceptor6
Hydrogen bond donor1
XlogP6.7
SynonymsBDBM50065971
Inchi KeyCJBOMVJKWSPOJY-NEEDMVDMSA-N
Inchi IDInChI=1S/C29H31F3N2O2/c1-3-19(2)27(33)18-34(28(35)26-17-25(26)22-7-5-4-6-8-22)23-13-9-20(10-14-23)21-11-15-24(16-12-21)36-29(30,31)32/h4-16,19,25-27H,3,17-18,33H2,1-2H3/t19-,25-,26+,27+/m0/s1
PubChem CID118727679
ChEMBLCHEMBL3400270
IUPHARN/A
BindingDB50065971
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has a partition coefficient log P greater than 5.

Experimental Data

ParameterValueReferenceDatabase source
EC50170.0 nMPMID25754495BindingDB,ChEMBL

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