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GPCR

NameGlucose-dependent insulinotropic receptor
SpeciesMus musculus (Mouse)
GeneGpr119
SynonymG protein-coupled receptor 119
G-protein coupled receptor 119
G-protein coupled receptor 2
glucose-dependent insulinotropic receptor
GPCR2
[ Show all ]
DiseaseN/A for non-human GPCRs
Length335
Amino acid sequenceMESSFSFGVILAVLTILIIAVNALVVVAMLLSIYKNDGVGLCFTLNLAVADTLIGVAISGLVTDQLSSSAQHTQKTLCSLRMAFVTSSAAASVLTVMLIAFDRYLAIKQPLRYFQIMNGLVAGACIAGLWLVSYLIGFLPLGVSIFQQTTYHGPCSFFAVFHPRFVLTLSCAGFFPAVLLFVFFYCDMLKIASVHSQQIRKMEHAGAMAGAYRPPRSVNDFKAVRTIAVLIGSFTLSWSPFLITSIVQVACHKCCLYQVLEKYLWLLGVGNSLLNPLIYAYWQREVRQQLYHMALGVKKFFTSILLLLPARNRGPERTRESAYHIVTISHPELDG
UniProtQ7TQP3
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL5263
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL3358007
Molecular formulaC21H22F4N6O3S
IUPAC name5-[(3R)-4-[5-[[2-fluoro-4-(methylsulfinylmethyl)phenyl]methoxy]pyrimidin-2-yl]-3-methylpiperazin-1-yl]-3-(trifluoromethyl)-1,2,4-oxadiazole
Molecular weight514.5
Hydrogen bond acceptor14
Hydrogen bond donor0
XlogP2.8
SynonymsBDBM50103545
Inchi KeyCMPJIODIHHCIRU-AUJFFYSJSA-N
Inchi IDInChI=1S/C21H22F4N6O3S/c1-13-10-30(20-28-18(29-34-20)21(23,24)25)5-6-31(13)19-26-8-16(9-27-19)33-11-15-4-3-14(7-17(15)22)12-35(2)32/h3-4,7-9,13H,5-6,10-12H2,1-2H3/t13-,35?/m1/s1
PubChem CID118722582
ChEMBLCHEMBL3358007
IUPHARN/A
BindingDB50103545
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has more than 10 hydrogen bond acceptor.
This ligand is heavier than 500 daltons.

Experimental Data

ParameterValueReferenceDatabase source
EC50106.0 nMPMID25286150BindingDB,ChEMBL
Intrinsic activity58.0 %PMID25286150ChEMBL

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