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GPCR

NameProbable G-protein coupled receptor 88
SpeciesHomo sapiens (Human)
GeneGPR88
SynonymGPR88
STRG
striatum-specific G-protein coupled receptor
DiseaseN/A
Length384
Amino acid sequenceMTNSSSTSTSSTTGGSLLLLCEEEESWAGRRIPVSLLYSGLAIGGTLANGMVIYLVSSFRKLQTTSNAFIVNGCAADLSVCALWMPQEAVLGLLPTGSAEPPADWDGAGGSYRLLRGGLLGLGLTVSLLSHCLVALNRYLLITRAPATYQALYQRRHTAGMLALSWALALGLVLLLPPWAPRPGAAPPRVHYPALLAAAALLAQTALLLHCYLGIVRRVRVSVKRVSVLNFHLLHQLPGCAAAAAAFPGAQHAPGPGGAAHPAQAQPLPPALHPRRAQRRLSGLSVLLLCCVFLLATQPLVWVSLASGFSLPVPWGVQAASWLLCCALSALNPLLYTWRNEEFRRSVRSVLPGVGDAAAAAVAATAVPAVSQAQLGTRAAGQHW
UniProtQ9GZN0
Protein Data BankN/A
GPCR-HGmod modelQ9GZN0
3D structure modelThis predicted structure model is from GPCR-EXP Q9GZN0.
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3399910
IUPHAR123
DrugBankN/A

Ligand

NameCHEMBL3400255
Molecular formulaC28H31FN2O
IUPAC name(1R,2R)-N-[(2S)-2-amino-4-methylpentyl]-N-[4-(3-fluorophenyl)phenyl]-2-phenylcyclopropane-1-carboxamide
Molecular weight430.567
Hydrogen bond acceptor3
Hydrogen bond donor1
XlogP5.7
SynonymsBDBM50065985
Inchi KeyDHKISGNPJIVJHZ-DOEKTCAHSA-N
Inchi IDInChI=1S/C28H31FN2O/c1-19(2)15-24(30)18-31(28(32)27-17-26(27)21-7-4-3-5-8-21)25-13-11-20(12-14-25)22-9-6-10-23(29)16-22/h3-14,16,19,24,26-27H,15,17-18,30H2,1-2H3/t24-,26-,27+/m0/s1
PubChem CID118727664
ChEMBLCHEMBL3400255
IUPHARN/A
BindingDB50065985
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has a partition coefficient log P greater than 5.

Experimental Data

ParameterValueReferenceDatabase source
EC502100.0 nMPMID25754495BindingDB,ChEMBL

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