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GPCR

NameProbable G-protein coupled receptor 88
SpeciesHomo sapiens (Human)
GeneGPR88
SynonymGPR88
STRG
striatum-specific G-protein coupled receptor
DiseaseN/A
Length384
Amino acid sequenceMTNSSSTSTSSTTGGSLLLLCEEEESWAGRRIPVSLLYSGLAIGGTLANGMVIYLVSSFRKLQTTSNAFIVNGCAADLSVCALWMPQEAVLGLLPTGSAEPPADWDGAGGSYRLLRGGLLGLGLTVSLLSHCLVALNRYLLITRAPATYQALYQRRHTAGMLALSWALALGLVLLLPPWAPRPGAAPPRVHYPALLAAAALLAQTALLLHCYLGIVRRVRVSVKRVSVLNFHLLHQLPGCAAAAAAFPGAQHAPGPGGAAHPAQAQPLPPALHPRRAQRRLSGLSVLLLCCVFLLATQPLVWVSLASGFSLPVPWGVQAASWLLCCALSALNPLLYTWRNEEFRRSVRSVLPGVGDAAAAAVAATAVPAVSQAQLGTRAAGQHW
UniProtQ9GZN0
Protein Data BankN/A
GPCR-HGmod modelQ9GZN0
3D structure modelThis predicted structure model is from GPCR-EXP Q9GZN0.
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3399910
IUPHAR123
DrugBankN/A

Ligand

NameCHEMBL3400216
Molecular formulaC29H34N2O
IUPAC name(1R,2R)-N-[(2S,3S)-2-amino-3-methylpentyl]-2-(3-methylphenyl)-N-(4-phenylphenyl)cyclopropane-1-carboxamide
Molecular weight426.604
Hydrogen bond acceptor2
Hydrogen bond donor1
XlogP5.9
SynonymsBDBM50065734
Inchi KeyDPHOSZXWSBLJKO-SKOFVLAMSA-N
Inchi IDInChI=1S/C29H34N2O/c1-4-21(3)28(30)19-31(25-15-13-23(14-16-25)22-10-6-5-7-11-22)29(32)27-18-26(27)24-12-8-9-20(2)17-24/h5-17,21,26-28H,4,18-19,30H2,1-3H3/t21-,26-,27+,28+/m0/s1
PubChem CID118727625
ChEMBLCHEMBL3400216
IUPHARN/A
BindingDB50065734
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has a partition coefficient log P greater than 5.

Experimental Data

ParameterValueReferenceDatabase source
EC501200.0 nMPMID25754495BindingDB,ChEMBL

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